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Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B…

Goldstein(Rebecca L),Yang(Shao Ning),Taldone… J Clin Invest 2016-02-04

...SYK and BTK. Consequently, treatment of BCR-dependent ABC DLBCL cells with PU-H71 attenuated BCR signaling, calcium flux...

CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cell…

Nakamura-Ishizu(Ayako),Takubo(Keiyo),Kobayas… J Exp Med 2016-04-12

...Syk, Lcp2, and Plcg2. Knockdown of these molecules in cultured Mks decreased expression of Thpo. Clec2(MkΔ/Δ) mice exhib...

Emerging roles of podoplanin in vascular development and homeostasis.

Pan(Yanfang),Xia(Lijun) Front Med 2016-09-23

...Syk kinase. This mechanism is required to initiate and maintain separation of blood and lymphatic vessels and to stabili...

Substrate Distortion and the Catalytic Reaction Mechanism of 5-Carboxyvanillate…

Vladimirova(Anna),Patskovsky(Yury),Fedorov(A… J Am Chem Soc 2016-10-24

...SYK-6 (kcat = 2.2 s(-1) and kcat/Km = 4.0 × 10(4) M(-1) s(-1)) and Novosphingobium aromaticivorans (kcat = 27 s(-1) and ...

Syk negatively regulates TLR4-mediated IFNβ and IL-10 production and promotes i…

Yin(Hui),Zhou(Huaxin),Kang(Yi),Zhang(Xiaoju)… Biochim Biophys Acta 2016-05-02

...Syk has been shown to associate with TLR4, the immune consequences of Syk-TLR interactions and related molecular mechani...

[CD22 signal abnormalities in the pathogenesis of immune related pancytopenia].

Wu(Xiaojing),Shao(Zonghong),Ruan(Erbao),Fu(R… Zhonghua Yi Xue Za Zhi 2016-03-01

...SYK( pSYK) + cells in the four groups had the same trend (all P <0. 05). The ratio of pCD22+ cells/pSYK+ cells in new di...

Inhibitory effect of fermented Arctium lappa fruit extract on the IgE-mediated …

Yoo(Jae-Myung),Yang(Ju Hye),Yang(Hye Jin),Ch… Int J Mol Med 2016-10-27

...Syk, which are involved in the FcεRI signaling pathway, that of phosphoinositide phospholipase C (PLC)γ1/2 and protein k...

Analysis of Multidomain Protein Dynamics.

Roy(Amitava),Hua(Duy P),Post(Carol Beth) J Chem Theory Comput 2016-10-12

...Syk protein kinase and by characterizing an effect of phosphorylation on the dynamics. Correlated motions are assessed f...

Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia …

Uematsu(Takayuki),Iizasa(Ei&#x27;ichi),Kobayashi(… Sci Rep 2016-09-28

...Syk or CARD9-deficient DCs but not macrophages showed impaired cytokine but not type-I interferon production in response...

Coordinated loss of microRNA group causes defenseless signaling in malignant ly…

Yamagishi(Makoto),Katano(Harutaka),Hishima(T… Sci Rep 2016-10-10

...SYK, PKCβII, PLCγ1, IKKβ, NIK, MYD88, PI3K class I (α/β/δ/γ), RasGRP3); signaling network habitually faces interference ...

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