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Banxia Houpo Decoction reduces lysosomal leakage of prefrontal astrocytes thr...

Yang(H),Peng(Q),Shuang(R),Guo(Z),Yang(H),C... J Ethnopharmacol 2026-03-25

...CTSB) interaction, O-GlcNAcylation, and NLRP3 inflammasome activation; western blotting for protein expression; immunofl...

Development of Cathepsin B-Responsive GalNAc-PROTACs for Hepatocyte-Targeting...

Peng(Y),Li(T),Liu(D),Li(W),Zhang(Y),Zhao(Y... J Med Chem 2026-01-08

...CTSB)-cleavable Val-Cit-PABC linker, we generated a prototype GalNAc-PROTAC conjugate, TMU454. TMU454 selectively degrad...

Proteotoxic stress triggers TFEB- and TFE3-mediated autophagy and lysosomal b...

Zhu(Z),Yang(J),Montefusco(S),Xia(S),Ou(J),... Autophagy 2026-04-00

...CTSB, cathepsin B; CTSD, cathepsin D; DQ-BSA, dequenched-bovine serum albumin; EIF4EBP1/4EBP1, eukaryotic translation in...

Organelle stress in NLRP3 inflammasome: a central mediator of neurodegenerati...

Jia(H),Ma(L),Liu(J),Gao(M),Liang(X),Zhang(... Mol Neurodegener 2026-01-03

...CTSB), and calcium ions (Ca2+), induce NLRP3 inflammasome activation. It further examines the pivotal role of organelle-...

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induc...

Zhao(Y),Zhang(Y),Rao(H),Sun(J),Pan(Z),Jin(... Adv Sci (Weinh) 2026-03-00

...CTSB) and led to decreased macrophage infiltration and diminished trophoblast invasion. Mechanistically, PFOA exposure l...

Cell senescence-related pathogenic genes in sleep disorders: a multi-omics Me...

Li(J),Ding(S),Zhang(X),Tang(L),Jiang(W) Eur Arch Psychiatry Clin Ne... 2026-06-00

...CTSB expression was associated with a reduced risk of sleep apnea (OR = 0.943, 95% CI = 0.905-0.983, P = 0.006, FDR = 0....

A manganese metabolism-related gene signature for prognosis prediction and im...

Man(Y),Chen(W),Shen(G),Zhao(X),Lu(J),Zhang(X) Discov Oncol 2026-01-31

...CTSB, SCG5, GALNT6 and AMPH) were used to establish the signature and independently validated using the CGGA-GBM dataset...

Effects of dietary nanoplastics exposure on muscle quality, immunity, antioxi...

Zhang(J),Fu(Q),Cheng(S),Ren(H),Mu(Y),Liu(J... Aquat Toxicol 2026-03-00

...ctsb). In the digestive gland, NPs induced lipid accumulation (increased to 1.20-fold of the control level in the NPs100...

Insulin-like growth factor-1 enhances β-amyloid protein clearance in HMC3 mic...

Guo(H),Peng(X),Zhang(X),Ruganzu(JB),Wu(X),... Exp Cell Res 2026-04-01

...CTSB) and cathepsin D (CTSD) expression. Consequently, these results demonstrated that IGF-1 promotes the internalizatio...

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance ...

Shen(D),Li(R),She(Y),Liu(X),Huang(Y),Ji(Y)... Adv Sci (Weinh) 2026-03-00

...CTSB and MFSD12 mediated by PRDM1. This state renders the PRDM1+ malignant cell cluster more susceptible to ferroptosis ...

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