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Evolutionary Signatures of Thermotolerance Shaped by Adaptive Admixtures in t...

Goli(RC),Chishi(KG),Sruthi(OS),Gunturu(T),... J Mol Evol 2026-07-24

...CTSL, and HSPA14 contributed to environmental adaptability, whereas ATP11A influenced lean meat yield. A 1000 SNP ancest...

MOTS-c, a mitochondrial-derived peptide, ameliorates lysosomal membrane perme...

Shi(J),Wu(Y),Liu(X),Xia(W),Wu(J),Lou(J),Zh... Autophagy 2026-06-02

...CTSL = cathepsin L, Co-IP = co-immunoprecipitation, DEGs = differentially expressed genes, ELISA = enzyme-linked immunos...

Prenatal dexamethasone exposure programs male offspring subfertility via GR/H...

Jin(S),Yao(Y),Zhu(L),Zhao(X),Li(M),Jiang(P... Chem Biol Interact 2026-08-06

...CTSL. Mechanistically, the activated Glucocorticoid Receptor (GR) recruited Histone Deacetylase 6 (HDAC6) to the Ctsl pr...

Cathepsin L potentiates autoimmunity by inhibiting lysosome-mediated STING de...

Xing(JQ),Zhang(ZH),Guo(ZL),Cai(H),Han(QY),... Front Immunol 2026-00-00

...CTSL) as a critical stabilizer of STING in cells. CTSL deficiency selectively impairs STING-induced IFN responses withou...

Association of Cathepsin Proteins with Alzheimer's Disease Risk: An Integrate...

Zhang(Q),Li(Q),Ai(Z),Li(F),Wang(Y),Zhou(W) Neuromolecular Med 2026-06-18

...CTSL was the most coherent signal across observational analyses, showing associations with AD diagnosis, poorer cognitiv...

Identification and Analysis of the Mpp5Ab1-Interacting Protein in the Midgut ...

Huang(Y),Li(Q),Wang(J),Wang(Y),Liao(D),Sun... Toxins (Basel) 2026-05-29

...CTSL, and Cb-TsetseEP. Subsequent bimolecular fluorescence complementation (BiFC) assays in Sf9 cells specifically confi...

Development and Validation of an Anoikis-Related Machine Learning Signature f...

Wu(J),Zhang(B),Liu(H) Cancers (Basel) 2026-06-17

...CTSL, GOLM1, ICAM3, MTUS1, and SERPINH1. The signature showed prognostic value in TCGA-LUAD and GSE26939 and demonstrate...

PM2.5 promotes lung cancer progression by upregulating CTSL to relieve autoph...

Zhang(C),Xu(F),Wu(S),Li(M),Li(Y),Guo(M),Li... Ecotoxicol Environ Saf 2026-09-01

...CTSL is a key molecular target in PM2.5-driven lung cancer progression. Targeting CTSL may offer new strategies for prev...

CTSL loss leads to anti-PD-1 immunotherapy resistance in lung cancer by suppr...

Wang(Y),Huang(J),Zou(X),Xu(J) Front Immunol None

...CTSL and NLRP3 inflammasome activation in mediating the anti-tumor function of CD8+ T cells. CTSL expression in peripher...

Integrative ATAC-Seq and RNA-Seq analysis identifies key genes for intramuscu...

Li(J),Wang(J),Wang(Y),Mao(R),Zhao(X) BMC Genomics 2026-07-02

...CTSL (top 10 highest IMF correlation) and GTF3C3 (with the most significant ACR at its transcription start site), both c...

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