...IAPP) aggregates as a major contributor to the loss of β-cell mass in type 2 diabetes. Prevention of IAPP formation repr...
...IAPP were employed to shed light on the structural basis for the interaction of Cu(II) with human IAPP. Our results show...
...IAPP) self-associates into toxic assemblies causing islet β-cell death. Therefore, preventing IAPP toxicity is a promisi...
...IAPP) is a hormone cosecreted with insulin. IAPP proceeds through a series of conformational changes from random coil to...
...IAPP) and enhanced its toxicity to INS-1 beta cells. Heparin increased amyloid deposition in cultured human islets, but ...
...IAPP) might contribute to β-cell dysfunction and disease. However, the mechanism of protein aggregation and associated t...
...IAPP, amylin) implicated in type 2 diabetes and α-synuclein, which is linked to Parkinson's disease. Work in the last 10...
...IAPP, amylin) as an example, but the methods are general.
...IAPP derivative with a restricted conformational ensemble that co-assembles with IAPP, we observed that helical species ...
...IAPP (rIAPP) differs from hIAPP at six positions, does not form amyloid, and is an inhibitor of amyloid formation by hIA...
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