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Malic enzyme 1 senses L-lactate to determine tumor heterogeneity.

Cao(SY),Hu(K),Huang(S),Guan(XL),Wang(J),Shen… Signal Transduct Target Ther 2026-09-11

...ME1R155A mutation, which disrupts L-lactate binding, abolishes the protumorigenic effect of the L-lactate-ME1 axis on tu...

Loss of hepatic ME1 ameliorates MASLD by Suppressing peroxisomal β-Oxidation an…

Zhang(J),Wu(D),Lei(R),Zhang(F),Wu(W),Wu(Y),Z… J Adv Res 2026-06-00

...ME1) as a susceptibility gene for metabolic disorders in humans. However, the role and mechanisms of ME1 in regulating h...

Solubility prediction and cytotoxicity of lipidic microemulsion: HSPiP modeling…

Alnemer(OA),Hussain(A),Altamimi(MA) Sci Rep 2025-09-29

...ME1-ME3) were prepared after optimizing Smix at varied ratios (surfactant to co-surfactant ratio) and evaluated for size...

Identification of lipid metabolism-related signature in nonalcoholic fatty live…

Sun(Y),Hu(M),Yang(J),Jia(D),Gao(C),Wang(W) Eur J Med Res 2025-10-13

...ME1) were identified as significantly correlated with lipid metabolism in NAFLD. The nomogram model, based on the two ke...

Effect of Folate Deficiency on the Changes of Histone H3 Lysine 4 Monomethylati…

Xie(Q),Hu(J),Li(JT),Zhang(T) Zhongguo Yi Xue Ke Xue Yuan X… 2025-10-00

Objective To investigate the effects of folate deficiency on changes in histone H3 lysine 4 (H3K4) mono-methylation (me1...

Characteristic Gene Alterations During Fatty Acid Metabolism in the Goose Liver.

Koseniuk(A) Genes (Basel) 2025-09-25

...ME1 (malic enzyme 1), SCD1 (stearoyl-CoA desaturase), ACSL1 (acyl-CoA synthetase long-chain family member 1), and ELOVL6...

Multi-omics analysis of gut-liver axis reveals the mechanism by which sulforaph…

Zhang(C),Shi(H),Wang(B),Ma(J),Sun(X),Liu(Y),… Comp Biochem Physiol Part D G… 2025-12-00

...ME1, CPT1B). The microbiota composition were changed in SFN + TPT, including the increased of beneficial Fusobacteriota ...

Comprehensive multi-omics analysis of glioma tissues via LC-MS and GC-MS reveal…

Pienkowski(T),Mojsak(P),Zelkowska(J),Solowie… J Pharm Biomed Anal 2025-12-15

...ME1. These insights broaden our understanding of glioma progression, highlighting novel biomarkers and potential therape...

Comprehensive Analysis of Liver Transcriptome and Metabolome Response to Oncoge…

Zhi(L),Xu(X),Zeng(Y),Qin(W),Li(G),Zhao(J),Zh… Biology (Basel) 2025-07-25

...ME1-NADP+-malic acid potentially mediate functional crosstalk between sphingolipid metabolism and cellular redox homeost...

Genome-wide selection signal analysis reveals the adaptability of Tibetan sheep…

Song(Y),Yuan(C),Guo(T),Chen(B),Wang(F),Lu(Z)… Front Vet Sci 2025-00-00

...ME1, ACSL6, PIK3C2G), melanogenesis (MITF, EP300), and the HIF-1 signaling pathway (ERBB2, HIF1A, RELA). Among these, th...

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