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Predictors of first line treatment failure in classic Hodgkin lymphoma: A com...

Alibrahim(MN),Gloghini(A),Carbone(A) Crit Rev Oncol Hematol 2025-12-00

...PTPN1) contributing to immune evasion, particularly in non-responders. Despite these advancements, a critical gap remain...

Macrophage PTP1B regulates mitochondrial dynamics via the JAK2/STAT3-OPA1 axi...

Lei(X),Qian(D),Zhang(W),Zhao(B),Li(Y),Hao(... Front Immunol 2025-00-00

...Ptpn1 (encoding PTP1B, Ptpn1-/-) in macrophages significantly alleviated tendon inflammation and fibrosis, indicating a ...

Endothelial CYB5R3 couples store-operated calcium entry to TRPV2 activation a...

Katona(M),Yuan(S),Hall(R),Romito(O),Taicle... bioRxiv 2025-10-08

...PTPN1). This prevented TRPV2 dephosphorylation, thereby maintaining Janus kinase 1 (JAK1)-dependent channel activation d...

Uncovering the individual immunotherapeutic roles of PTPN1 and PTPN2 in T cel...

Perez-Quintero(LA),Poirier(AJ),Feng(CH),Ma... iScience 2025-10-17

...PTPN1/2 deletion on T cell cytotoxicity. Our results show that while PTPN2 functionally dominates over PTPN1, additional...

Pro-inflammatory cytokines as regulators of protein tyrosine phosphatases and...

Stein(V),Geserick(P),Friedrich(K),Brinschw... Cell Signal 2025-11-00

...PTPN1/PTP1B) and type 2 (PTPN2/TCPTP) were evaluated after cytokine stimulation and addressed by pharmacological inhibit...

Unraveling genetic predisposition and oxidative stress in vitiligo developmen...

Kocić(H),Lotti(T),Jevtović-Stoimenov(T),Wo... J Med Biochem 2025-07-04

...PTPN1, PTPN22, NLRP1, FASLG, and TYR. These genes influence the immune response and melanocyte function, with the transc...

Comprehensive genetic analysis based on multi - omics reveals novel therapeut...

Chen(B),Wang(C),Li(W) Int J Cardiol 2025-08-15

...PTPN1, the remaining 7 genes were all significantly genetically associated with MVP, and LDSC analysis further showed th...

(20S)-protopanaxatriol attenuates Ang II-induced renal injury via PTPN1-media...

Zhao(R),Wang(Z),Liu(C),Zhang(L),Zhang(M),D... J Ginseng Res 2025-11-00

...PTPN1 and inhibited the AMPK/mTOR signaling pathway, thereby effectively alleviating autophagy dysregulation in both ren...

Development of Novel PTPN2/1 Inhibitors for the Treatment of Melanoma.

Wang(D),Song(M),Tong(C),Wang(W),Li(Q),Liu(... J Med Chem 2025-10-23

...PTPN1 have emerged as promising therapeutic targets, yet developing effective inhibitors faces significant drug-like pro...

Genome wide DNA copy number analysis in cholangiocarcinoma using high resolut...

Arnold(Alexander),Bahra(Marcus),Lenze(Dido... Exp Mol Pathol 2016-02-01

...PTPN1) within these regions of chromosomal instability. Next to common aberrations in IH-CCA and EH-CCA, we additionally...

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