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Tumor promoter binding of the protein kinase C C1 homology domain peptides of...

Irie(Kazuhiro),Masuda(Akiko),Shindo(Mayumi... Bioorg Med Chem 2005-08-15

...RasGRP2 showed significant phorbol 12,13-dibutyrate (PDBu) binding, but the K(d) values of the RasGRP1 and RasGRP3 C1 pe...

F-actin-dependent translocation of the Rap1 GDP/GTP exchange factor RasGRP2.

Caloca(Mariía J),Zugaza(José L),Vicente-Ma... J Biol Chem 2004-06-15

...RasGRP2, a Rap1-specific exchange factor with low affinity toward diacylglycerol. The regulation of RasGRP2 during signa...

Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras...

Clyde-Smith(J),Silins(G),Gartside(M),Grimm... J Biol Chem 2000-11-13

...RasGRP2, a longer alternatively spliced form of the recently cloned RapGEF, CalDAG-GEFI. A unique feature of RasGRP2 is ...

Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide R...

Czikora(Agnes),Lundberg(Daniel J),Abramovi... J Biol Chem 0000-00-00

...RasGRP2 with the mutated C1 domain, phorbol ester enhanced the ability of the mutated RasGRP2 to activate Rap1. Modeling...

A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2...

Ren(Jinqi),Cook(Aaron A),Bergmeier(Wolfgan... Biochem Biophys Res Commun 0000-00-00

...RasGRP2 at Ser394 located in the linker region implicated in its autoinhibition. These studies identify RasGRP2 as a nov...

Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activati...

Lozano(María Luisa),Cook(Aaron),Bastida(Jo... Blood 0000-00-00

...RASGRP2 gene is strongly expressed in platelets and neutrophils, where its encoded protein CalDAG-GEFI facilitates the a...

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