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Receptor homodimerization significantly prolongs the lifetime of ligand-induced…

Clark(JC),Martin(EM),Slater(A),Calebiro(D),K… Blood Vessel Thromb Hemost 2026-05-00

...Syk. The results show that, when expressed at low level, GPVI and CLEC-2 diffuse over the cell surface as monomers with ...

Platelet lipid rafts: Disease regulatory hubs and precision therapeutic targets…

Zhao(A),Liu(Q),Wang(X),Wang(Y),Wang(Z),Liu(Z) Biochem Biophys Res Commun 2026-08-20

...Syk and Src family kinases. Consequently, platelet lipid rafts modulate a spectrum of physiological and pathological eve...

Integrated analyses of single-cell transcriptome and mendelian randomization re…

Cai(HX),Ma(GP),Jia(Z),Liu(FY),Wu(G),Lu(RZ),Z… J Geriatr Cardiol 2026-07-28

...SYK pathway. Additionally, in vitro results demonstrated that CD74 impairs lymphangiogenesis by inducing pyroptosis. Thi...

Sinomenine modulates an MGAT3-associated B-cell IgG N-glycosylation pathway lin…

Liu(P),Zhang(J),Wang(J),Li(R),Tian(R),Wang(S… Pharmacol Res 2026-09-14

...Syk/NF-κB signaling with increased TNF-α, IL-6, and IL-1β. Mechanistically, sinomenine (SIN) bound to MGAT3, as supporte...

Protective Effects of the Ethanolic Leaf Extract of Ocimum sanctum L. on Collag…

Maaz(M),Balupillai(A),Periyakali(S),Padhan(J… Molecules 2026-08-07

...SYK, PLCγ2, P2RY12, and PI3Kβ. Some phytoconstituents showed good binding affinities, with apigenin having the highest b...

Vialinin A Inhibits Microtubule-Mediated Secretory Granule Transport for Degran…

Tagne(AMD),Ishii(K),Yoshioka(Y),Sugaya(K),On… Molecules 2026-08-13

...Syk kinase activity, a key protein involved in the development of allergic rhinitis. However, its effect on other calciu...

Purified Compounds from Phyllanthus amarus Schum. & Thonn. Inhibit Mast Cell De…

Vo(TS),My(VTN),Luan(PVH),Ngo(DH) Molecules 2026-08-14

...Syk and PLCγ, suggesting inhibition of the degranulation-related signaling cascade. These findings provide preliminary i...

Anti-inflammatory effects of Pyrus pyrifolia extract via modulation of Src/Syk-…

Su(J),Huang(L),Oh(Y),Zhang(J),You(L),Kaskada… Food Sci Biotechnol 2026-08-00

...Syk kinases and inhibited downstream PI3K-AKT-IKK signaling. Molecular docking and cellular thermal shift assays support...

Low-molecular-weight components of placental extract inhibit degranulation by b…

Fujii(Y),Hashimoto(S),Komatsu(Y),Suzuki(R),H… Mol Biol Rep 2026-08-29

...Syk, an upstream signaling component, but inhibited the phosphorylation of ERK1/2, which modulates cytokine production. ...

Integrative transcriptomics identifies shared aging-associated inhibitory-neuro…

Fan(W),Han(S),Wang(C),Gao(J) J Mol Neurosci 2026-08-29

...SYK, and TNFSF13B. Among them, RGL2 emerged as the leading candidate, with the strongest downstream support concentrated...

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