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Full-length spleen tyrosine kinase inhibits the invasion and metastasis of huma…

Li(Zhihai),Cai(Zhiyi),Tao(Baohong),Jin(Qiaoz… Int J Clin Exp Pathol 2016-10-31

...SYK (L) expression were transfected with pIRES2-EGFP-SYK (L) vector and empty vector pIRES2-EGFP to generate Hep-2-SYK (...

Atheroprotection through SYK inhibition fails in established disease when local…

Lindau(Alexandra),Härdtner(Carmen),Hergeth(S… Basic Res Cardiol 2016-10-21

...SYK) may participate in downstream signaling of various receptors that mediate these processes. We tested the effect of ...

Structural and Kinetic Characterization of the 4-Carboxy-2-hydroxymuconate Hydr…

Mazurkewich(Scott),Brott(Ashley S),Kimber(Ma… J Biol Chem 2016-08-15

...SYK-6. The structure of GalB was determined and found to be a member of the PIG-LN-acetylglucosamine deacetylase family;...

Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer'…

Ghosh(Soumitra),Geahlen(Robert L) EBioMedicine 2016-11-04

...SYK, is recruited. SYK enhances the formation of SGs, is active within the resulting SGs and stimulates the production o...

RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint …

Bednarski(Jeffrey J),Pandey(Ruchi),Schulte(E… J Exp Med 2016-08-15

...SYK tyrosine kinase and BLNK adaptor, resulting in suppression of pre-BCR signaling. This regulatory circuit prevents th...

β-Glucan-Activated Human B Lymphocytes Participate in Innate Immune Responses b…

Ali(Mohamed F),Driscoll(Christopher B),Walte… J Immunol 2016-03-15

...SYK, MAPKs, and the transcription factors NF-κB and AP-1. Moreover, we observed that conditioned media from β-glucan-sti...

Human Neutrophils Use Different Mechanisms To Kill Aspergillus fumigatus Conidi…

Gazendam(Roel P),van Hamme(John L),Tool(Anto… J Immunol 2016-06-13

...Syk, PI3K, and protein kinase C to trigger the production of toxic reactive oxygen metabolites by the NADPH oxidase and ...

(E)-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone displays suppression of infl…

Kim(Yong),Jeong(Eun Jeong),Han Lee(In-Sook),… Korean J Physiol Pharmacol 2016-01-25

...Syk, Akt, and IκBα, were also blocked by this compound. It was confirmed that MPP was able to suppress autophosphorylati...

Network-Based Meta-Analyses of Associations of Multiple Gene Expression Profile…

He(Hao),Cao(Shaolong),Niu(Tianhua),Zhou(Yu),… PLoS One 2016-07-08

...SYK) were identified based on gene expression meta-analysis, and their associations with BMD were also replicated by two...

A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Jo…

Ferguson(Gregory D),Delgado(Mercedes),Plante… PLoS One 2016-07-19

...Syk kinase inhibitor, CC-509. This compound is a potent inhibitor of purified Syk enzyme, FcR-dependent and FcR-independ...

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