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Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer'…

Ghosh(Soumitra),Geahlen(Robert L) EBioMedicine 2016-11-04

...SYK, is recruited. SYK enhances the formation of SGs, is active within the resulting SGs and stimulates the production o...

Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Developme…

Lee(Ellen J),Brown(Brieanna R),Vance(Emily E… J Immunol 2016-08-03

...Syk and Card9. In contrast, Dectin-1 contributed minimally and a possible repressive role was shown for Dectin-2. These ...

Interventions for the management of fatigue in adults with a primary brain tumo…

Day(Julia),Yust-Katz(Shlomit),Cachia(David),… Cochrane Database Syst Rev 2016-07-21

...SYK, DC) independently evaluated search results, extracted data from selected studies and carried out a bias risk assess...

Targeting Syk in Autoimmune Rheumatic Diseases.

Deng(Guo-Min),Kyttaris(Vasileios C),Tsokos(G… Front Immunol 2016-03-25

Spleen tyrosine kinase (Syk) is a member of the Src family of non-receptor tyrosine kinases, which associates directly w...

Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses …

Németh(Tamás),Futosi(Krisztina),Sitaru(Cassi… Nat Commun 2016-08-19

...Syk, PLCγ2, Bcl10/Malt1 and NFκB. Collectively, CARD9-mediated gene expression changes within neutrophils play important...

The Syk Inhibitor Fostamatinib Decreases the Severity of Colonic Mucosal Damage…

Can(Guray),Ayvaz(Suleyman),Can(Hatice),Demir… J Crohns Colitis 2016-08-09

...Syk, and phospho-Syk expression.,There was a significant difference between the colitis and control groups in terms of a...

SYK expression endows human ZAP70-deficient CD8 T cells with residual TCR signa…

Hauck(Fabian),Blumenthal(Britta),Fuchs(Sebas… Clin Immunol 2016-02-29

...SYK that correlated with residual TCR signaling including calcium flux and degranulation. Our findings highlight the dif...

Progress in Small Molecule Therapeutics for the Treatment of Retinoblastoma.

Pritchard(Eleanor M),Dyer(Michael A),Guy(R K… Mini Rev Med Chem 2016-11-01

...SYK) inhibitors.

Lectin binding to surface Ig variable regions provides a universal persistent a…

Linley(Adam),Krysov(Sergey),Ponzoni(Maurilio… Blood 2016-01-14

...SYK inhibitor (tamatinib) or the BTK inhibitor (ibrutinib) each blocked phosphorylation. Activation by DC-SIGN occurred ...

RAC1 P29S regulates PD-L1 expression in melanoma.

Vu(Ha Linh),Rosenbaum(Sheera),Purwin(Timothy… Pigment Cell Melanoma Res 2016-06-22

...Syk as being selectively upregulated with RAC1 P29S expression and downregulated with RAC1 P29S depletion. Using the mel...

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