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Transcriptomic analysis of global changes in cytokine expression in mouse splee…

He(Jun-Jun),Ma(Jun),Song(Hui-Qun),Zhou(Dong-… Parasitol Res 2016-09-07

...Syk-Card9 signaling pathways, were upregulated. We believe our study is the first comprehensive attempt to define the ho...

Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome …

Viganò(Elena),Diamond(Catherine Emma),Spreaf… Nat Commun 2016-05-17

...Syk activity and Ca(2+) flux instigated by CD14/TLR4-mediated LPS internalization. Identification of caspase-4/5 as the ...

Integration of innate into adaptive immune responses in ZAP-70-positive chronic…

Wagner(Michaela),Oelsner(Madlen),Moore(Andre… Blood 2016-06-14

...Syk. Notably, expression of ZAP-70 appears to be of crucial importance for TLR9-mediated activation of Syk. We show that...

Comparable actions of omalizumab on mast cells and basophils.

Serrano-Candelas(E),Martinez-Aranguren(R),Va… Clin Exp Allergy 2016-10-13

...Syk, PLCγ, and LAT) and in a decrease in degranulation and leukotriene synthesis.,Our data prove the existence of common...

FOXO1 activation is an effector of SYK and AKT inhibition in tonic BCR signal-d…

Szydlowski(Maciej),Kiliszek(Przemyslaw),Sewa… Blood 2016-06-29

...SYK activity, and was associated with longer overall survival. These results demonstrate that FOXO1 is required for SYK ...

Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A System…

Dunster(Joanne L),Mazet(Francoise),Fry(Micha… PLoS Comput Biol 2016-04-13

...Syk tyrosine phosphorylation and activation. Our approach reveals the central importance of this negative feedback pathw...

FcγRIIIa-Syk Co-signal Modulates CD4+ T-cell Response and Up-regulates Toll-lik…

Chauhan(Anil K),Moore(Terry L),Bi(Ye),Chen(C… J Biol Chem 2016-06-02

...Syk. A role for FcγRIIIa activation from immune complex (IC) ligation and sublytic terminal complement complex (C5b-9) i...

[Genetic basis of immune response of lymphocyte-like cells in the mucosal immun…

Xin(Liu),Xueying(Song),Xiaoping(Zhang),Yingl… Yi Chuan 2016-01-11

...Syk, Btk and Blnk were not changed significantly, indicating the activation of TCR-like signal transduction pathway afte...

Cerdulatinib, a novel dual SYK/JAK kinase inhibitor, has broad anti-tumor activ…

Ma(Jiao),Xing(Wei),Coffey(Greg),Dresser(Kare… Oncotarget 2016-10-07

...SYK and JAK/STAT pathways. On a tissue microarray of 62 primary DLBCL tumors, 58% expressed either phosphorylated SYK or...

The natural compound nujiangexanthone A suppresses mast cell activation and all…

Lu(Yue),Cai(Shuangfan),Nie(Jia),Li(Yangyang)… Biochem Pharmacol 2016-06-22

...Syk dependent pathways. N7 inhibited histamine release, prostaglandin D2 and leukotriene C4 generation in mast cell depe...

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