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Imatinib therapy in clonal eosinophilic disorders, including systemic mastocy...

Tefferi(Ayalew),Pardanani(Animesh) Int J Hematol 2004-07-20

...PDGFRB), which have been pathogenetically linked to clonal eosinophilia, and their presence predicts complete as well as...

Promoter-binding and repression of PDGFRB by c-Myc are separable activities.

Mao(Daniel Y L),Barsyte-Lovejoy(Dalia),Ho(... Nucleic Acids Res 2004-07-13

...PDGFRB). Using chromatin immunoprecipitation, we show that c-Myc binds to the proximal promoter of the PDGFRB gene in pr...

HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leuke...

Morerio(Cristina),Acquila(Maura),Rosanda(C... Cancer Res 2004-06-10

...PDGFRB/HCMOGT-1 fusion. We show that the breakpoint of PDGFRB occurred at the same site of all previously reported PDGFR...

NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in...

Vizmanos(José L),Novo(Francisco J),Román(J... Cancer Res 2004-06-10

We describe a new PDGFRB fusion associated with a t(5;14)(q33;q24) in a patient with a longstanding chronic myeloprolife...

Disruption of the PDGFB gene in a 1;22 translocation patient does not cause C...

Sutajová(Markéta),Neukirchen(Ursula),Meine... Genomics 2004-10-26

...PDGFRB, revealed no pathogenic mutations. Reevaluation of the clinical symptoms of the translocation patient challenges ...

Imatinib targets other than bcr/abl and their clinical relevance in myeloid d...

Pardanani(Animesh),Tefferi(Ayalew) Blood 2004-11-04

...PDGFRB) tyrosine kinases. The drug has acquired therapeutic relevance because of similar inhibitory activity against cer...

Molecular and cytogenetic characterization of a novel translocation t(4;22) i...

Safley(Anne Michele),Sebastian(Siby),Colli... Genes Chromosomes Cancer 2004-05-25

...PDGFRB has been well established, to our knowledge there are only two previous reports describing a BCR-PDGFRA fusion ge...

Imatinib therapy for hypereosinophilic syndrome and eosinophilia-associated m...

Pardanani(Animesh),Tefferi(Ayalew) Leuk Res 2004-07-22

...PDGFRB gene that is located on chromosome 5q33. Furthermore, response to therapy has been rapid (within days) and durabl...

A 2-year-old with atypical CML with a t(5;12)(q33;p13) treated successfully w...

Wittman(Brenda),Horan(John),Baxter(Joanna)... Leuk Res 2004-07-22

...PDGFRB. Because the PDGFRB tyrosine kinase is one of the known targets of tyrosine kinase inhibitors, this patient achie...

High incidence of BCR-ABL kinase domain mutations and absence of mutations of...

Al-Ali(Haifa-Kathrin),Heinrich(Michael Cha... Hematol J 2004-09-30

...PDGFRB as possible causes of resistance in patients without ABL mutations.

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