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Syk inhibitors with high potency in presence of blood.

Thoma(Gebhard),Blanz(Joachim),Bühlmayer(Pete… Bioorg Med Chem Lett 2015-02-20

...Syk inhibitors which potently abrogate Syk kinase function in enzymatic assays, cellular assays and in primary cells in ...

Phosphoproteomic analyses reveal that galectin-1 augments the dynamics of B-cel…

Tsai(Chih-Ming),Wu(Hsin-Yi),Su(Tseng-Hsiung)… J Proteomics 2015-01-19

...Syk, Btk, and PI3K may be dominant in galectin-1-mediated activation. We further demonstrated that the proliferation of ...

IgE regulates the expression of smMLCK in human airway smooth muscle cells.

Balhara(Jyoti),Redhu(Naresh Singh),Shan(Lian… PLoS One 2015-01-15

...Syk knock down and pharmacological inhibition of mitogen activated protein kinases (MAPK) (ERK1/2, p38, and JNK) and pho...

Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antif…

Wevers(Brigitte A),Kaptein(Tanja M),Zijlstra… Cell Host Microbe 2015-01-12

...Syk-CARD9-mediated PKB signaling, that leads to loss of nuclear IRF1 activity, hence blocking IL12A transcription. The a...

An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulat…

Yasukawa(Shinsuke),Miyazaki(Yoshiyuki),Yoshi… Nat Commun 2015-08-04

...Syk or NLRP3, but not MyD88, is sufficient to abolish CHS. All tested haptens, but not irritants, can induce Syk activat...

Optimal aggregation of FcεRI with a structurally defined trivalent ligand overr…

Mahajan(Avanika),Barua(Dipak),Cutler(Patrick… ACS Chem Biol 2015-02-26

...Syk to override phosphatase-mediated negative regulatory signals.

A meta-analysis of somatic mutations from next generation sequencing of 241 mel…

Xia(Junfeng),Jia(Peilin),Hutchinson(Katherin… Mol Cancer Ther 2015-04-20

...SYK, and KDR), including five genes (RAC1, ADAMTS18, EPHA7, TAF1L, and NF1) with a recurrent mutation in at least two "p...

Characterization of the catabolic pathway for a phenylcoumaran-type lignin-deri…

Takahashi(Kenji),Kamimura(Naofumi),Hishiyama… Biodegradation 2015-03-30

...SYK-6, and identified some of the DCA catabolism genes. In SYK-6 cells, the alcohol group of DCA was oxidized to the car...

SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFAT…

Mukai(Tomoyuki),Ishida(Shu),Ishikawa(Remi),Y… J Bone Miner Res 2015-07-14

...SYK) and phospholipase Cγ2 (PLCγ2) phosphorylation, leading to increased nuclear translocation of NFATc1. The heterozygo...

CD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor…

Myers(Dorothea E),Yiv(Seang),Qazi(Sanjive),M… Integr Biol (Camb) 2015-04-17

...SYK) P-site inhibitor C61. C61-loaded LNP were decorated with a murine CD19-specific monoclonal antibody directed agains...

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