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CD5 negatively regulates the T-cell antigen receptor signal transduction pathwa…

Perez-Villar(JJ),Whitney(GS),Bowen(MA),Hewgi… Mol Cell Biol 1999-04-00

...Syk, and phospholipase Cgammal but not the Src family tyrosine kinase p56(lck). By mutation of all four CD5 intracellula...

Crystal structure of an aromatic ring opening dioxygenase LigAB, a protocatechu…

Sugimoto(K),Senda(T),Aoshima(H),Masai(E),Fuk… Structure 1999-08-15

...SYK-6 utilizes an extradiol-type catecholic dioxygenase, the LigAB enzyme (a protocatechuate 4,5-dioxygenase), to oxidiz...

The B cell-restricted adaptor BASH is required for normal development and antig…

Hayashi(K),Nittono(R),Okamoto(N),Tsuji(S),Ha… Proc Natl Acad Sci U S A 2000-03-14

...Syk after BCR ligation and binds to various signaling proteins. BASH structurally resembles SLP-76, which is essential f...

Fibrillar beta-amyloid-stimulated intracellular signaling cascades require Vav …

Wilkinson(B),Koenigsknecht-Talboo(J),Grommes… J Biol Chem 2006-07-28

...Syk kinases. The downstream target of Vav, the small GTPase Rac1, is GTP-loaded in an Abeta-dependent manner. Rac1 is bo...

An immunoreceptor tyrosine activation motif in the mouse mammary tumor virus en…

Ross(SR),Schmidt(JW),Katz(E),Cappelli(L),Hul… J Virol 2006-09-00

...Syk tyrosine kinase (E. Katz, M. H. Lareef, J. C. Rassa, S. M. Grande, L. B. King, J. Russo, S. R. Ross, and J. G. Monro...

Evidence for distinct pathomechanisms in genetic subgroups of chronic lymphocyt…

Kienle(DL),Korz(C),Hosch(B),Benner(A),Merten… J Clin Oncol 2005-06-01

...SYK and PI3K. The characteristic gene expression patterns observed implicate a differential regulation of cell cycle, ap...

The Epstein-Barr virus protein, latent membrane protein 2A, co-opts tyrosine ki…

Ingham(RJ),Raaijmakers(J),Lim(CS),Mbamalu(G)… J Biol Chem 2005-10-07

...Syk tyrosine kinases. LMP2A also associates through its two PPPPY motifs with AIP4, a NEDD4 family E3 ubiquitin ligase; ...

Differing mechanisms of cAMP- versus seawater-induced oocyte maturation in mari…

Stricker(SA),Smythe(TL) Mol Reprod Dev 2006-12-00

...Syk, reduced GVBD and MAPK/MPF activities in SW-, but not cAMP-induced maturation. Similarly, inhibitors of the human ep...

Identification of protein tyrosine kinases required for B-cell- receptor-mediat…

Lavens(S),Faust(EA),Lu(F),Jacob(M),Leta(M),L… J Virol 2004-08-00

...Syk and Btk and that it is positively regulated by Lyn. Thus, the use of DT40 cells has allowed us to delineate the earl...

Effects of arachidonic acid analogs on FcepsilonRI-mediated activation of mast …

Nakano(N),Nakao(A),Uchida(T),Shirasaka(N),Yo… Biochim Biophys Acta 2005-12-30

...Syk and linker for activation of T cells (LAT) were enhanced, whereas, in MA- or PA-supplemented cells, they were not ch...

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