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Medical countermeasure against respiratory toxicity and acute lung injury follo…

Nambiar(MP),Gordon(RK),Rezk(PE),Katos(AM),Wa… Toxicol Appl Pharmacol 2007-03-00

...syk oligonucleotides 2 min post-exposure did not significantly increase the survival rate of VX-exposed guinea pigs. Fur...

Dysregulation of Src family kinases in mast cells from epilepsy-resistant ASK v…

Kitaura(J),Kawakami(Y),Maeda-Yamamoto(M),Hor… J Immunol 2007-01-01

...Syk activity, prolonged activation of ERK and JNK, and enhanced activation of Akt. Furthermore, the lipid raft-resident ...

Mast cell inhibitor R112 is well tolerated and affects prostaglandin D2 but not…

Guyer(BJ),Shimamoto(SR),Bradhurst(AL),Grossb… Allergy Asthma Proc 2006-00-00

...Syk, in an allergen challenge model of AR. We also examined the effects of R112 on symptoms, mediator release, and nasal...

Role of focal adhesion tyrosine kinases in GPVI-dependent platelet activation a…

Carrim(N),Walsh(TG),Consonni(A),Torti(M),Ber… PLoS One 2014-00-00

...Syk), PI3-K and Bruton's tyrosine kinase (Btk) and upstream of Rac1, PLCγ2, Ca2+ release, PKC, Hic-5, NOX1 and αIIbβ3 ac...

Commonality and differences of methylation signatures in the plasma of patients…

Melson(J),Li(Y),Cassinotti(E),Melnikov(A),Bo… Int J Cancer 2014-06-01

...SYK and GPC3) AUC = 0.8177, Sens = 0.6316 Spec = 0.840. In a validation cohort, N = 10 CRC patients, the optimal CRC sig...

Gnetin H isolated from Paeonia anomala inhibits FcεRI-mediated mast cell signal…

Kim(M),Lim(SJ),Oidovsambuu(S),Nho(CW) J Ethnopharmacol 2014-07-03

...Syk, protein kinase C (PKC)μ, phospholipase Cγ, and the mitogen-activated protein kinases, c-Jun N-terminal kinase, p38,...

Telomerase upregulation is a postcrisis event during senescence bypass and imm…

Degerman(S),Siwicki(JK),Osterman(P),Lafferty… Aging Cell 2010-04-00

...SYK. Telomerase upregulation was thus found to be uncoupled to escape of growth crisis but rather a later event in the i...

HIV inhibits early signal transduction events triggered by CD16 cross-linking o…

Lichtfuss(GF),Meehan(AC),Cheng(WJ),Cameron(P… J Leukoc Biol 2011-01-00

...Syk/Zap70 tyrosine kinase activity, and that there is a significant correlation between CD107a mobilization and pSyk/Zap...

Response of adult mouse uterus to early disruption of estrogen receptor-alpha s…

Simmons(CD),Pabona(JM),Zeng(Z),Velarde(MC),G… J Endocrinol 2010-05-00

...Syk), with loss of Klf9, alone or in concert with DES. Our data support a molecular network between KLF9 and ESR1 in the...

Hypoxemic resuscitation from hemorrhagic shock prevents lung injury and attenua…

Douzinas(EE),Betrosian(A),Giamarellos-Bourbo… Free Radic Biol Med 2011-01-15

...Syk inhibitors and monosodium urate crystals, IL-8 release was reduced. We conclude that hypoxemic resuscitation from he...

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