We describe the fusion of TP53BP1 to PDGFRB in a patient with a chronic myeloid leukemia-like disorder associated with e...
The TEL-PDGFRB fusion oncogene is associated with chronic myelomonocytic leukemia (CMML) and results in the expression o...
...PDGFRB, and in four patients PDGFRB was shown to be phosphorylated/expressed.,After a treatment period of > or = 1 year,...
...PDGFRB) gene at chromosome band 5q33 have been described in some patients, the most common being the t(5;12)(q33;p13). A...
...PDGFRB. Scatchard analysis of the saturation data demonstrated an approximately twofold increase both in the number of P...
...PDGFRB and AE into lethally irradiated syngeneic mice. These mice (19/19, 100%) developed AML resembling M2-AML that was...
...PDGFRB fusion gene. The fourth patient had leukocytosis, eosinophilia, and a t(5;12) translocation involving PDGFRB and ...
...PDGFRB or FGFR1. These translocations result in the production of constitutively active tyrosine kinase fusion proteins ...
...PDGFRB and FGFR1. This contrasts with the frequent involvement of genes encoding transcription factors or other nuclear ...
...PDGFRB), a receptor tyrosine kinase that maps to 5q33. PDGFRB is disrupted by other translocations and to date four addi...
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