...SYK-6 results in a nearly five-fold increase in pyruvate production. We further demonstrate the aerobic conversion of py...
...Syk) inhibitors with favorable druglike properties is described. Early leads were discovered through X-ray crystallograp...
...Syk tyrosine kinase activity was required and sufficient to induce cell death. Hyperactive Syk was functionally equivale...
...Syk)-dependent tyrosine phosphorylation cascade. Thereby, CLEC-2 not only contributes to thrombus formation and stabiliz...
...SYK rearrangement. T cell clonality was detected by multiplex PCR analysis of TRG and TRD gene rearrangements. After 4 c...
...Syk activation. Moreover, the cross-linking of CD13 with antibodies rapidly induced pSyk in human macrophages. Finally, ...
...SYK and LYN are critical for the activation of mutant PLCG2 and that therapeutics targeting SYK and LYN can combat molec...
...Syk, or by IgG antibodies acting via inhibitory Fcγ receptors. Recent reports indicate that such interventions have prom...
...SYK) and phospho-SYK. In vitro, paclitaxel-resistant cells expressed higher SYK, and the ratio of phospho-SYK/SYK positi...
...Syk) inhibition for more effective chronic graft-versus-host disease (cGVHD) treatment.
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