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Mechanism of outside-in {alpha}IIb{beta}3-mediated activation of human platelet…

Keane(C),Petersen(H),Reynolds(K),Newman(DK),… Arterioscler Thromb Vasc Biol 2010-12-00

...Syk] and phospholipase C [PLC]-γ2). Tyrosine phosphorylation of FcγRIIa resulted in platelet-dense granule secretion, fi...

Biomarkers of Autoimmune Chronic Spontaneous Urticaria.

Larenas-Linnemann(D) Curr Allergy Asthma Rep 2023-00-00

...SYK) or reduced activation of the inhibitory Src homology 2 (SH2)-containing inositol phosphatases (SHIP)-related pathwa...

N-WASP-dependent branched actin polymerization attenuates B-cell receptor signa…

Bhanja(A),Seeley-Fallen(MK),Lazzaro(M),Upadh… Elife 2023-00-12

...Syk, the inhibitory phosphatase SHIP-1, and their phosphorylated forms in individual BCR clusters. These results suggest...

Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A System…

Dunster(JL),Mazet(F),Fry(MJ),Gibbins(JM),Tin… PLoS Comput Biol 2015-11-00

...Syk tyrosine phosphorylation and activation. Our approach reveals the central importance of this negative feedback pathw...

Proteomic modulation in breast tumors after metformin exposure: results from a …

Kalinsky(K),Zheng(T),Hibshoosh(H),Du(X),Mund… Clin Transl Oncol 0000-00-00

...Syk; and reductions in pMAPK, JNK, Bad, PKC.alpha, and Src. Cyclin D1 change after metformin by IHC was not observed. In...

Changes in the gene expression and methylation in chicken cecal tonsils after i…

Dunislawska(A),Gryzinska(M),Siwek(M) Sci Rep 2023-00-13

...SYK, ANGPTL4, TNFRSF14, IKZF1, CYR61, SERPING. Analyzes showed that the suppression of gene expression is related to the...

Improving the power of clinical trials of rheumatoid arthritis by using data on…

Wason(James M S),Jenkins(Martin) Rheumatology (Oxford) 0000-00-00

...SyK Inhibition in Rheumatoid Arthritis-1) to assess its performance in comparison to a standard method treating patients...

Expression of SOCS1 and CXCL12 Proteins in Primary Breast Cancer Are Associated…

Smolkova(Bozena),Mego(Michal),Horvathova Kaj… Transl Oncol 2016-06-09

...SYK, TIMP3, BRMS1, and SOCS1 proteins in primary breast tumor tissue was evaluated by immunohistochemistry. CTCs with ep...

Reversion of Asthmatic Complications and Mast Cell Signalling Pathways in BALB/…

Gupta(Kriti),Kumar(Sandeep),Gupta(Rinkesh Ku… J Biomed Nanotechnol 2016-07-12

...Syk, c-Yes, PI-3, p-PI-3, PLC-γ2, and p-PLC-γ2 were found to be reduced in the OVA sensitized BALB/c mice treated with n...

Multi-omics network pharmacology and computational validation reveal amodiaquin…

Kurmi(SPC),Fayek(FH),Mishra(VK),Nagaraja(S),… Comput Biol Chem 2026-08-00

...SYK, and KCNH2. Amodiaquine and Desethylamodiaquine both showed high binding scores (-7.9 to -12.6 kcal·mol⁻¹) across al...

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