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Ibrutinib Therapy Releases Leukemic Surface IgM from Antigen Drive in Chronic L…

Drennan(S),Chiodin(G),D'Avola(A),Tracy(I),Jo… Clin Cancer Res 2019-04-15

...SYK, which lies upstream of BTK in the B-cell receptor pathway. This specific IgM increase in patients underpins the key...

Profiling the origin, dynamics, and function of traction force in B cell activa…

Wang(J),Lin(F),Wan(Z),Sun(X),Lu(Y),Huang(J),… Sci Signal 2018-00-07

...Syk, Btk, PLC-γ2, BLNK, and Vav3) and adaptor molecules (Grb2, Cbl, and Dok-3) linking BCR microclusters and motor prote...

Lymphocyte activation gene 3: a novel therapeutic target in chronic lymphocytic…

Shapiro(M),Herishanu(Y),Katz(BZ),Dezorella(N… Haematologica 2017-00-00

...SYK, BTK and MAPK signaling. Moreover, LAG3 blocking antibody enhanced in vitro T-cell activation. Our data suggest that...

TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism…

Singh(RK),Haka(AS),Asmal(A),Barbosa-Lorenzi(… Arterioscler Thromb Vasc Biol 2020-00-00

...SYK (spleen tyrosine kinase), PI3K (phosphoinositide 3-kinase), and Akt in agLDL catabolism using the lysosomal synapse....

Comprehensive transcriptome profiling of the chicken bursa infected with the no…

Xiong(H),Wu(J),Wang(S),Zhang(J),Zhang(W),Wan… Poult Sci 2025-12-12

...SYK) were significantly down-regulated, indicating impaired humoral immunity. Competing endogenous RNA (ceRNA) network a...

Exposure to silver nanoparticles primes mast cells for enhanced activation thro…

Alsaleh(NB),Mendoza(RP),Brown(JM) Toxicol Appl Pharmacol 2019-00-01

...Syk, PLCγ and LAT. Our findings indicate that pre-exposure to AgNPs exacerbates mast cell allergen-mediated phosphorylat...

Macrophage Trem2 deficiency aggravates aging-induced vascular remodeling by act…

Chen(Y),Zeng(Z),Wei(Z),Zhan(Y),Wu(L),Zhu(X),… Mol Biomed 2025-12-29

...Syk-Sp1-SLC25A51 pathway to enhance mitochondrial nicotinamide adenine dinucleotide (NAD)⁺ transport. This triggered met...

The Inflammatory Nexus: Unraveling Shared Pathways and Promising Treatments in …

Russo(AP),Pastorello(Y),Dénes(L),Brînzaniuc(… Int J Mol Sci 2025-06-27

...SYK), the mechanistic (or mammalian) target of rapamycin (mTOR), and the S100 calcium-binding protein B (S100B)/receptor...

Signaling Cross-Talk between MHC Class II Molecular Conformers in Resting Murin…

Drake(JR) Immunohorizons 2019-00-18

...Syk protein tyrosine kinase activity. In contrast, multimerized forms of two different anti-I-Ak mAbs that bind both M1-...

Human thioredoxin, a damage-associated molecular pattern and Malassezia-crossre…

Roesner(LM),Ernst(M),Chen(W),Begemann(G),Kie… Sci Rep 2019-00-01

...Syk kinase function was performed to investigate downstream signaling, which led to diminished hTrx responses. In our ex...

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