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Hypoxia-induced decreases in SOCS3 increase STAT3 activation and upregulate V...

Yokogami(Kiyotaka),Yamashita(Shinji),Takes... Brain Tumor Pathol 2014-03-25

...SOCS3 abolished the hypoxia-induced STAT3 activation and the STAT3-mediated transcriptional upregulation of the VEGF gen...

Regulation of hepatic suppressor of cytokine signaling 3 by zinc.

Liuzzi(Juan P),Wong(Carmen P),Ho(Emily),Tr... J Nutr Biochem 2014-04-24

...SOCS3. In addition, we tested the role of MTF-1 in the regulation of SOCS3 expression using EMSA, chromatin immunoprecip...

FXR ligands protect against hepatocellular inflammation via SOCS3 induction.

Xu(Zhizhen),Huang(Gang),Gong(Wei),Zhou(Pen... Cell Signal 2014-01-30

...SOCS3), which is a negative feedback regulator of cytokine-STAT3 signaling. We then demonstrated that the beneficial eff...

Angiotensin-converting enzyme 2 attenuates oxidative stress and VSMC prolifer...

Song(Bei),Jin(Haiyan),Yu(Xi),Zhang(Zhenzho... Regul Pept 2014-04-21

...SOCS3) expression and phosphorylation levels of JAK2, STAT3 and ERK1/2 linked with elevated superoxide production and ce...

Overexpression of suppressor of cytokine signaling 3 in the arcuate nucleus o...

Ganjam(Goutham K),Benzler(Jonas),Pinkenbur... J Comp Physiol B 2014-07-07

...SOCS3), in the arcuate nucleus (ARC) of LD hamsters relative to hamsters in SD. The alteration in SOCS3 gene expression ...

Immunochemoradiotherapy for patients with oral squamous cell carcinoma: augme...

Tano(Tomoyuki),Okamoto(Masato),Kan(Shin),B... Neoplasia 2014-01-30

...SOCS3. Antisense oligonucleotides for SOCS1 and SOCS3 markedly reduced OK-432-induced IL-10 and TGF-β. This is the first...

Low level methylmercury enhances CNTF-evoked STAT3 signaling and glial differ...

Jebbett(Nathan J),Hamilton(Joshua W),Rand(... Neurotoxicology 2014-10-24

...SOCS3), and increases the proportion of cells expressing GFAP following 2 days of differentiation. Higher, near-cytotoxi...

Huang-lian-jie-du-tang protects rats from cardiac damages induced by metaboli...

Li(Chuan Bao),Li(Xiao Xing),Chen(Yu Guo),G... PLoS One 2014-04-24

...SOCS3, IRS1 and AKT in the heart was detected by immunohistochemistry and Western blot analysis. Compared with the contr...

Suppressive oligodeoxynucleotides promote the development of Th17 cells.

Bode(Christian),Yang(Xiang-Ping),Kiu(Hiu),... PLoS One 2014-02-07

...SOCS3) inhibition. In vivo studies show that treatment with Sup ODN promotes Th17 responsiveness under physiological con...

Critical and independent role for SOCS3 in either myeloid or T cells in resis...

Carow(Berit),Reuschl(Ann-Kathrin),Gavier-W... PLoS Pathog 2014-02-18

...SOCS3 in M. tuberculosis infection was examined. All Socs3(fl/fl) LysM cre, Socs3(fl/fl) lck cre (with SOCS3-deficient m...

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