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Spleen tyrosine kinase (Syk) inhibitor fostamatinib limits tissue damage and fi…

Pamuk(Omer Nuri),Can(Guray),Ayvaz(Suleyman),… Clin Exp Rheumatol 2015-10-26

...Syk, phospho-Syk, and TGF-β expression decreased in both skin and lung tissues.,The Syk inhibitor fostamatinib prevented...

Processing of CD74 by the Intramembrane Protease SPPL2a Is Critical for B Cell …

Hüttl(Susann),Kläsener(Kathrin),Schweizer(Mi… J Immunol 2015-11-24

...Syk. We provide evidence that in SPPL2a(-/-) mice impaired BCR signaling is to a great extent provoked by the accumulati...

Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Cen…

Polikowsky(Hannah G),Wogsland(Cara E),Diggin… J Immunol 2015-11-24

...SYK and other membrane-proximal BCR effectors in the absence of BCR engagement. These findings reveal that stage-specifi...

Macrophage-Inducible C-Type Lectin/Spleen Tyrosine Kinase Signaling Pathway Con…

He(Yue),Xu(Liang),Li(Bo),Guo(Zhen-Ni),Hu(Qin… Stroke 2015-10-19

...Syk, and p-Syk increased at 12 hours and peaked at 24 hours after SAH. Mincle small interfering RNA reduced interleukin-...

Fonsecaea pedrosoi-induced Th17-cell differentiation in mice is fostered by Dec…

Wüthrich(Marcel),Wang(Huafeng),Li(Mengyi),Le… Eur J Immunol 2015-11-26

...Syk/Card9 pathway is required for fungal recognition by host cells, it is not sufficient for host control. Exogenously a...

Rhamnus davurica leaf extract inhibits Fyn activation by antigen in mast cells …

Kim(Ji Hyung),Kim(A-Ram),Kim(Hyuk Soon),Kim(… BMC Complement Altern Med 2015-12-04

...Syk, which is the pivotal signaling protein for mast cell activation by antigen. Furthermore, LERD also impeded the acti...

Syk tyrosine kinase is critical for B cell antibody responses and memory B cell…

Ackermann(Jochen A),Nys(Josquin),Schweighoff… J Immunol 2015-07-21

...Syk protein tyrosine kinase. Earlier work with the DT40 chicken B cell leukemia cell line showed that Syk was required t...

Targeting Syk-activated B cells in murine and human chronic graft-versus-host d…

Flynn(Ryan),Allen(Jessica L),Luznik(Leo),Mac… Blood 2015-09-04

...Syk was necessary in donor B cells, but not T cells, for disease progression. Bone marrow-specific Syk deletion in vivo ...

Substrate stiffness regulates B-cell activation, proliferation, class switch, a…

Zeng(Yingyue),Yi(Junyang),Wan(Zhengpeng),Liu… Eur J Immunol 2015-08-18

...Syk molecules compared with antigens on softer substrates. In vitro expansion of mouse primary B cells shows different p...

Distinct pathways regulate Syk protein activation downstream of immune tyrosine…

Manne(Bhanu Kanth),Badolia(Rachit),Dangelmai… J Biol Chem 2015-07-16

...Syk are not completely understood. In this study, we identified a novel signaling mechanism in CLEC-2-mediated Syk activ...

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