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Aromatic catabolic pathway selection for optimal production of pyruvate and lac…

Johnson(CW),Beckham(GT) Metab Eng 2015-03-00

...SYK-6 results in a nearly five-fold increase in pyruvate production. We further demonstrate the aerobic conversion of py...

Leishmania infantum amastigotes trigger a subpopulation of human B cells with a…

Andreani(G),Ouellet(M),Menasria(R),Gomez(AM)… PLoS Negl Trop Dis 2015-02-00

...Syk, phosphatidylinositol-3 kinase and p38, as well as to require intracellular calcium mobilization. Cell sorting exper...

GRID and docking analyses reveal a molecular basis for flavonoid inhibition of …

Wright(Bernice),Watson(Kimberly A),McGuffin(… J Nutr Biochem 0000-00-00

...Syk, PKC, PIM1/2, ERK, JNK and PKA. X-ray crystallographic analyses of kinase-flavonoid complexes show that flavonoid ri...

Cutaneous Lupus Erythematosus: An Update on Pathogenesis and Future Therapeutic…

Niebel(D),de Vos(L),Fetter(T),Brägelmann(C),… Am J Clin Dermatol 2023-07-00

...SYK) inhibitors might broaden the therapeutic armamentarium in the near future. A close interdisciplinary exchange with ...

Lectin binding to surface Ig variable regions provides a universal persistent a…

Linley(Adam),Krysov(Sergey),Ponzoni(Maurilio… Blood 2016-01-14

...SYK inhibitor (tamatinib) or the BTK inhibitor (ibrutinib) each blocked phosphorylation. Activation by DC-SIGN occurred ...

Biochemical and structural characterization of a sphingomonad diarylpropane lya…

Kuatsjah(E),Zahn(M),Chen(X),Kato(R),Hinchen(… Proc Natl Acad Sci U S A 2023-00-24

...SYK-6, for which activity was confirmed in vivo. For both enzymes, we first demonstrated that formaldehyde is the C1 rea...

IgE-dependent human basophil responses are inversely associated with the sarcop…

Selnø(ATH),Sumbayev(VV),Gibbs(BF) Front Immunol 2022-00-00

...SYK) and inhibitory (e.g. SHIP-1) intracellular signals are associated with basophil responsiveness, which is also criti...

Analyses of lncRNAs, circRNAs, and the Interactions between ncRNAs and mRNAs in…

Wang(A),Wang(J),Mao(M),Zhao(X),Li(Q),Xuan(R)… Genes (Basel) 2023-00-10

...SYK, and ZAP70 through competitive binding with miR-141-x, miR-29-y, and chi-miR-29b-3p, thereby affecting the natural k...

Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activat…

Musumeci(L),Kuijpers(MJ),Gilio(K),Hego(A),Th… Circulation 2015-02-17

...Syk tyrosine phosphorylation, subsequently reducing phosphorylation of phospholipase Cγ2 and calcium fluxes. To investig...

Cell type-specific differences in β-glucan recognition and signalling in porcin…

Baert(K),Sonck(E),Goddeeris(BM),Devriendt(B)… Dev Comp Immunol 2015-01-00

...Syk-dependent pathway was only partly involved in these responses. We may conclude that CR3 plays a cardinal role in β-g...

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