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Ligation of TLR2, but not of TLR4 or other Toll-like receptors, induces neutrop…

Mosha(HT),de Carvalho Oliveira(V),Tatsiy(O),… J Immunol 2026-04-15

...Syk, PI3K, PLCγ2); acts through endogenous factors that bind the RAGE receptor; and involves PAD4 as well as endogenous ...

Crosstalk Between Clec7a and TLR4 Immune Pathway Drives Renal Damage in a Cispl…

Zhang(W),Xue(F),Shi(X),Fu(H),Shi(W),Guan(C),… FASEB J 2026-04-15

...Syk and TLR4/NF-κB promotes and sustains the inflammatory phenotypes of M1 macrophages, contributing to damage in AKI. T...

Dectin1 contributes to hypertensive vascular injury by promoting macrophage inf…

Zhang(J),Tu(Y),Wei(J),Zheng(R),Shao(J),Chen(… Biochim Biophys Acta Mol Basi… 2024-00-00

Vascular injury is an early manifestation leading to end-organ damage in hypertension pathogenesis, which involves a mac...

Equus β-Defensin-1 Regulates Innate IMMUNE Response in S. aureus-Infected Mouse…

Pei(L),Liu(K),Wei(W),Su(H),Li(F),Feng(Y),Wan… Animals (Basel) 2022-10-27

...Syk and IκB-α. In addition, OEBD-1 enhances the macrophage's ability to phagocytose S. aureus. In conclusion, Equus BD-1...

Perfluorooctane sulfonate attenuates IgE/Ag-stimulated mast cell activation and…

Sim(KH),Park(KM),Lee(C),Lee(YJ) Chemosphere 2025-03-00

...Syk and Lck, central tyrosine kinases in IgE/Ag-stimulated mast cell activation, along with their downstream signaling m...

Inflammatory genes are novel prognostic biomarkers for colorectal cancer.

Jiang(H),Dong(L),Gong(F),Gu(Y),Zhang(H),Fan(… Int J Mol Med 2018-07-00

...SYK) in this module were inflammatory genes, emphasizing the critical role of inflammation in CRC. In conclusion, these ...

Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascul…

Nakamura(J),Watanabe(S),Kimura(H),Kobayashi(… Sci Rep 2018-00-15

...Syk. Furthermore, the induction of AAV-IL-10 prevented the expression of TNF-α and IL-6, but not GM-CSF and Dectin-2 at ...

Chronic Lymphocytic Leukemia-Derived IL-10 Suppresses Antitumor Immunity.

Alhakeem(SS),McKenna(MK),Oben(KZ),Noothi(SK)… J Immunol 2018-00-15

...Syk/MAPK pathway. Our results suggest that incorporation of IL-10 blocking agents may enhance current therapeutic regime...

In Silico Analysis of Novel circRNA-miRNA-mRNA Axis in BRAFV600E Melanoma: Impl…

Naik(H),Choudhary(R),Konkimalla(VB) J Gene Med 2025-06-00

...SYK, HMOX1, IL33, CFH, FGF1, COL8A1, and ADAMTS3 as the primary gene signatures, while VCAM-1 and SNAI2 dominate as prom...

Ibrutinib Therapy Releases Leukemic Surface IgM from Antigen Drive in Chronic L…

Drennan(S),Chiodin(G),D'Avola(A),Tracy(I),Jo… Clin Cancer Res 2019-04-15

...SYK, which lies upstream of BTK in the B-cell receptor pathway. This specific IgM increase in patients underpins the key...

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