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p47phox deficiency impairs platelet function and protects mice against arterial…

Wang(X),Zhang(S),Ding(Y),Tong(H),Xu(X),Wei(G… Redox Biol 2020-00-00

...Syk and PLCγ2. Moreover, CRP or thrombin-stimulated p47phox-/- platelets displayed reduced intracellular ROS generation ...

Therapeutic Strategies Targeting TREM2 for Alzheimer's Disease: Current Advance…

Yu(Y),Xu(Y),Xu(M) Curr Neuropharmacol 2026-09-22

...SYK axis, TREM2 regulates microglial phagocytosis, metabolism, and inflammatory responses. In Alzheimer's disease, it mo...

Requirement of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein…

Martin(K),Touil(R),Cvijetic(G),Israel(L),Kol… Arthritis Rheumatol 2020-00-00

...Syk-dependent, FcγR-mediated production of reactive oxygen species or leukotriene B4 . Notably, pharmacologic MALT-1 pro...

Analysis of antigen receptor signaling in B cells from mice with a retrovirus-i…

Selvey(LA),Morse(HC),June(CH),Hodes(RJ) J Immunol 1995-01-01

...syk kinase, were not detected in MAIDS B cells in response to IgM cross-linking. The defect in tyrosine phosphorylation ...

Anti-CD33 monoclonal antibodies enhance the cytotoxic effects of cytosine arabi…

Balaian(L),Ball(ED) Exp Hematol 2005-02-00

...Syk/SHP-1 complex formations. Combined treatment of AML cells by ara-C or IDA with anti-CD33 mAb resulted in higher leve...

Inhibitors for proteins endowed with catalytic and non-catalytic activity which…

Costantino(L),Barlocco(D) Curr Med Chem 2004-10-00

...Syk, and Lck SH2 domains binding antagonists. In this field very good inhibitors derived from high affinity peptides wer...

Primary platelet signaling cascades and integrin-mediated signaling control ADP…

Karim(ZA),Choi(W),Whiteheart(SW) J Biol Chem 2008-05-02

...Syk and phosphatidylinositol 3-kinase. The convulxin-induced decrease was sensitive to both PKCalpha/beta and delta inhi...

HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major hi…

Atkins(KM),Thomas(L),Youker(RT),Harriff(MJ),… J Biol Chem 2008-04-25

...Syk-phosphoinositide 3-kinase (PI3K) cascade through the sequential actions of two sites, Nef EEEE(65) and PXXP(75). The...

An altered peptide ligand of type II collagen suppresses autoimmune arthritis.

Myers(LK),Tang(B),Rosioniec(EF),Stuart(JM),K… Crit Rev Immunol 2007-00-00

...Syk, a kinase ordinarily utilized by B cells. Activation of this alternative pathway is a novel observation and may repr...

Inhibitory effects of an ellagic acid glucoside, okicamelliaside, on antigen-me…

Kuba-Miyara(M),Agarie(K),Sakima(R),Imamura(S… Int Immunopharmacol 2012-04-00

...Syk (Tyr525/526) and PLCγ-1 (Tyr783 and Ser1248) were inhibited by OCS and aglycon. In DNA microarray-screening test, OC...

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