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An approach to identify SNPs in the gene encoding acetyl-CoA acetyltransferas...

Sodhi(Simrinder Singh),Ghosh(Mrinmoy),Song... PLoS One 2016-03-28

...ACAT2. Validation of expression of genes in the laboratory also supported the idea of differential expression of ACAT2 a...

Dysregulation of testicular cholesterol metabolism following spontaneous muta...

Akpovi(Casimir D),Murphy(Bruce D),Erickson... Biol Reprod 2016-05-09

...ACAT2, SR-BI, and ABCA1 was significantly higher in Npc1-/- than in WT mice. The level of apoptosis determined by ELISA ...

Hepatic ACAT2 knock down increases ABCA1 and modifies HDL metabolism in mice.

Pedrelli(Matteo),Davoodpour(Padideh),Degir... PLoS One 2015-02-02

...ACAT2 may affect HDL metabolism. The aim of this study was to reveal whether hepatic ACAT2 influences HDL metabolism.,WT...

Algal sterols are as effective as β-sitosterol in reducing plasma cholesterol...

Chen(Jingnan),Jiao(Rui),Jiang(Yue),Bi(Yanl... J Agric Food Chem 2015-04-08

...ACAT2) and hepatic 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase and up-regulation of hepatic low-density lipoprote...

Cholesterol-lowering activity of sesamin is associated with down-regulation o...

Liang(Yin Tong),Chen(Jingnan),Jiao(Rui),Pe... J Agric Food Chem 2015-10-26

...ACAT2), microsomal triacylglycerol transport protein (MTP), and ATP-binding cassette transporters subfamily G members 5 ...

Impact of SCP-2/SCP-x gene ablation and dietary cholesterol on hepatic lipid ...

Klipsic(Devon),Landrock(Danilo),Martin(Gre... Am J Physiol Gastrointest L... 2015-12-01

...ACAT2) in males. DKO exacerbated the high-cholesterol diet-induced hepatic cholesterol and glyceride accumulation, witho...

Functional characterization of two single nucleotide polymorphisms of acyl-co...

He(Xuelian),Leow(Koon-Yeow),Yang(Hongyuan)... Gene 2015-08-10

Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) plays a critical role in the formation of cholesteryl esters from ...

Deletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in ...

Lopez(Adam M),Posey(Kenneth S),Turley(Step... Biochem Biophys Res Commun 2015-05-01

...ACAT2, is the major cholesterol esterifying enzyme in the liver and small intestine (SI). Esterified cholesterol (EC) ca...

Intestine-specific MTP and global ACAT2 deficiency lowers acute cholesterol a...

Iqbal(Jahangir),Boutjdir(Mohamed),Rudel(La... J Lipid Res 2015-10-15

...ACAT2 esterifies cholesterol for secretion with chylomicrons. We hypothesized that free cholesterol accumulated during A...

Acyltransferase inhibitors: a patent review (2010-present).

Ohshiro(Taichi),Tomoda(Hiroshi) Expert Opin Ther Pat 2015-12-22

...ACAT2-selective inhibitors, may be potential therapeutics for the treatment of atherosclerosis, homozygous familial hype...

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