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Personalizing cancer therapy: the role of pharmacogenetics in overcoming drug...

Nafchi(HM),Solatzadeh(H),Hajimaghsoudi(E),... Mol Biol Rep 2025-08-02

...ERCC1 and XRCC1 - that influence the metabolism, efficacy and toxicity of widely used chemotherapeutic agents. In additi...

Inhibition of nucleotide excision repair proteins associated with cancer chem...

Gentile(F),Cros-Perrial(E),Jordheim(LP) Biochim Biophys Acta Rev Ca... 2025-10-00

...ERCC1/XPF, and give an overview of preclinical and clinical studies underlying this therapeutic approach, as well as det...

Epistatic interactions in DNA repair genes as biomarkers of susceptibility fo...

Kaur(K),Kaur(R) Mutat Res Genet Toxicol Env... 2025-00-00

...ERCC1 3'-UTR (C8092A) and ERCC1 Asn118Asn (C354T) gene polymorphisms with pesticide-induced DNA damage was determined by...

The Role of Epigenetic Biomarkers as Diagnostic, Predictive and Prognostic Fa...

Chilimoniuk(Z),Gładysz(K),Moniczewska(N),C... Cancers (Basel) 2025-08-12

...ERCC1 have also shown predictive value, while lncRNAs including MALAT1 and GAS6-AS1 remain less validated. Regarding pro...

SLX1 silencing overcomes Olaparib resistance in metastatic castration-resista...

Zhao(X),Feng(S),Nitie(X),Muluo(S),Lei(Y) Cancer Biol Ther 2025-12-00

...ERCC1-XPF, PLK1, and TOPBP1), impairing DNA repair complex stability. In vivo, SLX1-silenced DU145 xenografts treated wi...

Immunotherapy and senolytics in head and neck squamous cell carcinoma: phase ...

Liu(N),Wu(J),Deng(E),Zhong(J),Wei(B),Cai(T... Nat Med 2025-09-00

...Ercc1-deficient mice (premature aging), we found that senolytics enhance the therapeutic efficacy of immunotherapy in mu...

Transcriptional stress in aging: integrating experimental data and modeling t...

van de Grint(J),Raseta(M),Brandt(R),van Lo... Front Mol Biosci 2025-00-00

...Ercc1 -/-, Ercc1 d/-, and Xpg -/- mice-models with DNA repair deficiencies that exhibit a wide range of premature aging ...

Sex-Specific Association Between XPC rs2228001 Polymorphism and Parkinson's D...

Alvarado-Retana(KM),Ramos-Rosales(DF),Antu... Brain Sci 2025-09-18

...ERCC1 (rs11615), ERCC2 (rs13181), XPA (rs1800975), XPC (rs2228001), and XPF (rs1799801) was performed using TaqMan real-...

UVH6 regulates osmotic and heat stress tolerance by modulating transcription.

Kobayashi(K),Murakoshi(Y),Kanamori(K),Hide... Front Plant Sci 2025-00-00

...ercc1) were not osmosensitive. Signaling pathways involving UVR8 and SOG1 were not implicated in UVH6 mutation-induced i...

Ferritin-Conjugated PROTAC Strategy for ERCC1/XPF Degradation and Platinum Se...

Wang(S),Zhao(R),Wang(S),Gui(Z),Hou(M),Yan(... J Med Chem 2025-09-25

...ERCC1/XPF degradation and enhanced platinum delivery. NERiP selectively degrades ERCC1/XPF upon release in reductive tum...

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