Yan(P),Bu(X),Hou(T),Chen(L),Zhong(G),Huang(D… J Immunother Cancer 2026-01-14

...SPOP expression predicts a better response to anti-PD-1 treatment. Hence, our findings reveal a pivotal role of the SPOP...

Chen(S),Lin(J),Yang(Z),Wang(Y),Wang(Q),Wang(… Cell Death Differ 2026-03-00

...SPOP and the upregulation of the E3 ubiquitin ligase TRIM24 in human prostate cancer specimens. Mechanistically, SPOP mu...

Mirskaya(M),Isaksson(A),Lindgren(EC),Carlsso… Int Urogynecol J 2026-02-00

...sPOP; 1617 (28.3%) women with sPOP and 6669 (17.8%) women without sPOP rated their health as poor. sPOP was associated w...

Alamillo(L),Ng(DCM),Currie(J),Black(A),Pandi… Cell Rep Methods 2025-07-21

...SPOP (speckle-type POZ protein) degrons in the fast turnover of cell-cycle-related and DNA-binding hiPSC proteins. Upon ...

Zhang(Q),Zhou(Y),Zhao(J),Hu(L),Zhu(Z),Wang(H… J Med Chem 2025-07-24

...SPOP are rarely reported. Here, we identified DDO-4033 as a potent SPOP inhibitor through virtual screening and optimiza...

Maheremu(M),Zheng(B),Wen(H),Wei(Q),Lv(S) Transl Androl Urol 2025-07-30

...SPOP. We hypothesized that DDX17 can stabilize the AR by inhibiting SPOP-mediated ubiquitination, thereby maintaining AR...

Zhou(S),Du(Q),Xu(L),Kang(X) Clin Exp Med 2025-07-10

...SPOP, an adaptor of the Cullin 3 E3 ubiquitin ligase complex. SPOP binds to SYT12 and mediates SYT12's K48-linked polyub...

Wang(Z),Li(L),Ye(Q),Lei(Y),Lu(M),Ye(L),Kang(… J Clin Invest 2025-07-15

...SPOP-mutant tumor cells. This study identified SPOP as a positive regulator of nuclear size; the findings suggest tumors...

Zeng(J),Li(Q),Li(K),Yang(L),Xu(L),Wang(W),Ya… Front Immunol 2025-00-00

...SPOP group, significantly lower than the rates found in KRAS_PIK3CA group. KRAS_SPOP mutant MLAs, exhibited reduced immu...

Fiorentino(V),Germanà(E),Ricciardi(G),Capodi… Pathologica 2025-09-00

...SPOP interfering-RNA in two PCa cell lines (LNCaP, PC3) and western-blot analysis, we examined the role of SPOP silencin...