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AcTor, a novel mTOR stimulator, potentiates ixazomib for the treatment of acute…

Pattanayak(SP),Darawshi(O),Hajihassani(O),Wi… Mol Cancer 2026-05-27

...TSC2 inhibitor. Because inhibition of TSC2 results in increased sensitivity to proteasome inhibitors, we combined AcTor ...

TSC gene-associated lesions of the lung.

Szalai(F),Krencz(I),Burger(CD),Kornafeld(A),… Hum Pathol 2026-05-27

...TSC2 are responsible for the development of tuberous sclerosis complex (TSC) and various sporadic diseases, including sp...

Gene burden meta-analysis of 748 879 individuals identifies LGI1-ADAM23 protein…

Lal(JC),Leu(C),Boßelmann(CM),Ivaniuk(A),Pére… Epilepsia 2026-07-00

...TSC2 exhibited broader systemic involvement. Our study shows the potential of population-scale genomic data and suggests...

Research of Tuberous Sclerosis Complex (TSC)-Associated Neuropsychiatric Disord…

Zheng(F),Yu(T),Salim Ahmad(I),Zhao(X),Yuan(B… Pediatr Neurol 2026-08-00

...TSC2 genotypes (P < 0.05). TAND was pervasive. The adapted Chinese TAND Checklist enabled systematic assessment. TSC2 va...

CRISPR screen identifies autophagy inhibition (GNS561) as a PARP inhibitor (AZD…

Yu(T),Barayan(R),Song(L),Venkatasubramanian(… Cancer Metab 2026-06-24

...TSC2 sensitized SCLC cell lines to olaparib. Therapeutic strategies combining PARPi and autophagy inhibition demonstrate...

Late-Onset Diagnosis of Tuberous Sclerosis Complex Revealed by Renal Angiomyoli…

Fekih(A),Heni(W),Messaoudi(C),Selmi(Y),Touat… Clin Case Rep 2026-06-00

...TSC2. It is typically diagnosed in childhood, most often because of neurological or dermatological manifestations. Diagn...

Ebastine mitigates cisplatin-induced pulmonary injury associated with alteratio…

Aldabaan(NA),Abdel-Wahab(BA),El-Shoura(EAM),… Mol Biol Rep 2026-06-24

...TSC2, PI3K, PDK1, CD36, and IGF-1, and with increased expression of miRNA-101 and ULK1, as demonstrated by Western blott...

Decoding the Lymphangioleiomyomatosis (LAM) Niche Microenvironment via Integrat…

Chen(K),Zhao(S),Guo(M),Reza(H),Wagner(A),Cak… Eur Respir J 2026-06-25

...TSC2, leading to mTORC1 hyperactivation. While mTOR inhibitor sirolimus, the only FDA approved drug for this disease, st...

ENT1 inhibitor J4 restores cognitive function and white-matter integrity in a m…

Hsieh(CC),Tsou(YS),Huang(NK),Chen(TC),Li(SJ)… J Biomed Sci 2026-06-17

Tuberous sclerosis complex (TSC) is a hereditary disease caused by pathogenic mutations in the TSC1 or TSC2 genes, leadi...

Multisystem Imaging Features and Organ Co-Occurrence in Children With Tuberous …

Tan(Y),Guo(C),Liu(J),Fu(M),Wang(Y),Yuan(L) J Clin Ultrasound 2026-06-19

...TSC2 mutations (p > 0.05). However, patients with TSC2 mutations faced an elevated cumulative risk of renal angiomyolipo...

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