...TSC2 inhibitor. Because inhibition of TSC2 results in increased sensitivity to proteasome inhibitors, we combined AcTor ...
...TSC2 are responsible for the development of tuberous sclerosis complex (TSC) and various sporadic diseases, including sp...
...TSC2 exhibited broader systemic involvement. Our study shows the potential of population-scale genomic data and suggests...
...TSC2 genotypes (P < 0.05). TAND was pervasive. The adapted Chinese TAND Checklist enabled systematic assessment. TSC2 va...
...TSC2 sensitized SCLC cell lines to olaparib. Therapeutic strategies combining PARPi and autophagy inhibition demonstrate...
...TSC2. It is typically diagnosed in childhood, most often because of neurological or dermatological manifestations. Diagn...
...TSC2, PI3K, PDK1, CD36, and IGF-1, and with increased expression of miRNA-101 and ULK1, as demonstrated by Western blott...
...TSC2, leading to mTORC1 hyperactivation. While mTOR inhibitor sirolimus, the only FDA approved drug for this disease, st...
Tuberous sclerosis complex (TSC) is a hereditary disease caused by pathogenic mutations in the TSC1 or TSC2 genes, leadi...
...TSC2 mutations (p > 0.05). However, patients with TSC2 mutations faced an elevated cumulative risk of renal angiomyolipo...
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