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Inhibition of osteoclast activation by phloretin through disturbing αvβ3 integr…

Lee(Eun-Jung),Kim(Jung-Lye),Gong(Ju-Hyun),Pa… Biomed Res Int 2015-12-15

...Syk phosphorylation and phospholipase Cγ induction by RANKL in osteoclasts. These results suggest that phloretin was an ...

The role of Syk signaling in antifungal innate immunity of human corneal epithe…

Liu(Ying),Zhao(Guiqiu),Lin(Jing),Li(Cui),Li(… BMC Ophthalmol 2015-12-16

...Syk inhibitors. Activation of Syk and the role of Syk in regulating inflammatory cytokines and chemokines expression wer...

Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocyte…

Callaway(Justin B),Smith(Scott A),McKinnon(K… J Biol Chem 2015-09-29

...Syk) within 1 hpi. Syk induces elevated IL1B, TNF, and IL6 mRNA by 2 hpi. Syk mediates elevated IL-1β secretion by activ...

Effects of Cudrania tricuspidata Fruit Extract and Its Active Compound, 5,7,3',…

Lee(Taehun),Kwon(Jaeyoung),Lee(Dongho),Mar(W… J Agric Food Chem 2015-12-08

...Syk, LAT, and PLCγ and F-actin redistribution. These results indicate that MFC and its active compound, THDPI, inhibit m...

CBL controls a tyrosine kinase network involving AXL, SYK and LYN in nilotinib-…

Gioia(Romain),Trégoat(Claire),Dumas(Pierre-Y… J Pathol 2015-11-05

A tyrosine kinase network composed of the TAM receptor AXL and the cytoplasmic kinases LYN and SYK is involved in niloti...

Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation o…

Deng(Zihou),Ma(Shixin),Zhou(Hao),Zang(Aiping… Nat Immunol 2015-07-30

...Syk. Here we identify a crucial role for the tyrosine phosphatase SHP-2 in mediating CLR-induced activation of Syk. Abla...

An indoxyl compound 5-bromo-4-chloro-3-indolyl 1,3-diacetate, CAC-0982, suppres…

Lee(Jun Ho),Kim(Tae Hyung),Kim(Hyuk Soon),Ki… Toxicol Appl Pharmacol 2015-07-28

...Syk and its downstream signaling molecules, including LAT, Akt, Erk1/2, p38, and JNK. Notably, the tyrosine kinase assay...

Expression of dectin-1 and enhanced activation of NALP3 inflammasome are associ…

Feriotti(Claudia),Bazan(Silvia B),Loures(Flá… Front Microbiol 2015-09-21

...Syk kinase phosphorylation and expression of intracellular pro-IL-1β than B10.A cells. These findings led us to investig...

Molecular cloning, expression pattern, and molecular evolution of the spleen ty…

Liu(Chang),Su(Peng),Li(Ranran),Zhang(Qiong),… Dev Genes Evol 2015-05-22

...Syk homologue was identified in the lamprey Lampetra japonica (Lj-Syk). The cDNA fragment of Lj-Syk contains a 1953-bp o...

Impact of the PI3-kinase/Akt pathway on ITAM and hemITAM receptors: haemostasis…

Moroi(Alyssa J),Watson(Steve P) Biochem Pharmacol 2015-05-11

...Syk), linker for activation of T cells (LAT) and phospholipase C γ2 (PLCγ2) become activated, leading to platelet activa...

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