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Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigat…

Leal(SM),Cowden(S),Hsia(YC),Ghannoum(MA),Mom… PLoS Pathog 2010-07-01

...Syk were up-regulated in infected corneas. Additionally, we show that infected Dectin-1(-/-) corneas have impaired IL-1b...

Targeting allergen to FcgammaRI reveals a novel T(H)2 regulatory pathway linked…

Hulse(KE),Reefer(AJ),Engelhard(VH),Patrie(JT… J Allergy Clin Immunol 2010-01-00

...Syk, as well as the downstream molecule phosphoinositide 3-kinase. Inhibition of TSLP receptor upregulation triggered by...

Inhibition of human natural killer cell activity by influenza virions and hemag…

Mao(H),Tu(W),Liu(Y),Qin(G),Zheng(J),Chan(PL)… J Virol 2010-05-00

...Syk and ERK activation and granule exocytosis upon target cell stimulation, finally causing reduced cytotoxicity. These ...

p85-RhoGDI2, a novel complex, is required for PSGL-1-induced β1 integrin-mediat…

Luo(J),Xu(T),Li(C),Ba(X),Wang(X),Jiang(Y),Ze… Int J Biochem Cell Biol 2013-12-00

...Syk, the phosphorylation is not required for the adhesion. Taken together, we find that specific phosphorylations on 130...

Friends and Foes in Alzheimer's Disease.

Pauwels(EKJ),Boer(GJ) Med Princ Pract 2023-00-00

...SYK, C22, and C33 play a role in the physiopathology of AD. Furthermore, bacteria and viruses may trigger an overactive ...

Integrative transcriptomics identifies shared aging-associated inhibitory-neuro…

Fan(W),Han(S),Wang(C),Gao(J) J Mol Neurosci 2026-08-29

...SYK, and TNFSF13B. Among them, RGL2 emerged as the leading candidate, with the strongest downstream support concentrated...

B-cell receptor dependent phagocytosis and presentation of particulate antigen …

Minton(AR),Smith(LD),Bryant(DJ),Strefford(JC… Explor Target Antitumor Ther 2022-02-25

...SYK) and phosphatidylinositol 3-kinase delta (PI3Kδ) but was unaffected by inhibitors of Bruton's tyrosine kinase (BTK)....

KMT2B drives inflammation in endothelial cells and promotes atherosclerosis via…

Zhang(F),Fu(R),Lin(Z),Hu(Q),Zheng(D),Zhang(H… Cardiovasc Res 2026-08-26

...Syk and siFos were performed in RAECs. Western diet feeding of ApoE-/- mice resulted in elevated KMT2B expression and H3...

TREM2 as a central immunometabolic hub in Alzheimer's disease: linking microgli…

Yang(G),Xu(X),Xu(Y) Front Immunol None

...SYK, PI3K-AKT-mTOR, and PLCγ2, leading to microglial transcriptional and metabolic reprogramming. These processes are es...

The novel H S donor 4-carboxy-phenyl isothiocyanate inhibits mast cell degranul…

Marino(Alice),Martelli(Alma),Citi(Valentina)… Br J Pharmacol 0000-00-00

...Syk, cPLA-2 and PLCγ1 in antigen-stimulated RBL-2H3 cells.,Collectively, our results demonstrate that, by attenuating th...

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