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CX-4945, a Selective Inhibitor of Casein Kinase 2, Synergizes with B Cell Recep…

Mandato(E),Nunes(SC),Zaffino(F),Casellato(A)… Curr Cancer Drug Targets 2018-00-00

...SYK inhibitor Fostamatinib or the BTK inhibitor Ibrutinib in inducing DLBCL cell death. CX-4945 was equally effective in...

Agalactosyl IgG induces liver fibrogenesis via Fc gamma receptor 3a on human he…

Ho(CH),Chang(TT),Lin(HC),Wang(SF) J Pathol 2024-00-00

...SYK. Furthermore, agalactosyl IgG treatment increased fibrogenic factors in HSCs, including transforming growth factor (...

Novel peanut-specific human IgE monoclonal antibodies enable screens for inhibi…

Suber(J),Zhang(Y),Ye(P),Guo(R),Burks(AW),Kul… Front Immunol 2022-00-00

...SYK and ERK, signal transduction proteins downstream of FcϵRI. Engaging inhibitory cell surface receptors CD300a or Sigl...

Population Pharmacokinetics of Mivavotinib (TAK-659), a Dual Spleen Tyrosine Ki…

Li(C),Watson(K),Wang(S),Diderichsen(PM),Gupt… J Clin Pharmacol 2023-00-00

...SYK/FLT3), is under development for the treatment of patients with advanced malignancies. In this analysis, we evaluated...

Amyloid-beta modulates microglial responses by binding to the triggering recept…

Zhong(L),Wang(Z),Wang(D),Wang(Z),Martens(YA)… Mol Neurodegener 2018-00-27

...Syk and Akt in primary microglia as well as TREM2-mediated signaling in a reporter cell system. Lastly, the functional o...

Structure and Reaction Mechanism of the LigJ Hydratase: An Enzyme Critical for …

Hogancamp(TN),Mabanglo(MF),Raushel(FM) Biochemistry 2018-00-09

...SYK-6 catalyzes the reversible hydration of (3 Z)-2-keto-4-carboxy-3-hexenedioate (KCH) to 4-carboxy-4-hydroxy-2-oxoadip...

Distinct epigenetic and transcriptional profiles of Epstein-Barr virus-positive…

Hai(L),Friedel(D),Hinz(F),Hoffmann(DC),Doubr… Neuro Oncol 2025-05-15

...SYK kinase activity was enriched in EBV- tumors while JAK2 was overrepresented in EBV+ PCNSL. Epigenetic profiling revea...

Investigation of Genomic and Transcriptomic Risk Factors of Clopidogrel Respons…

Yang(G),Alarcon(C),Chanfreau(C),Lee(NH),Frie… Clin Pharmacol Ther 2025-05-00

...SYK and AKT1, suggesting an inhibitory role of LAIR1 in the Glycoprotein VI pathway. In summary, these findings suggest ...

Functionalized aluminum hydroxide-based self-adjuvanted nanovaccine orchestrate…

Ling(X),Tian(Z),Chen(D),Zhang(Y),Dong(Z),He(… J Control Release 2025-02-10

...Syk and Raf1 signaling pathways and leading to upregulated TNFSF15 and OX40L expression to activate APCs. Following immu...

Curcumenol Inhibits Mast Cells Activation in Ovalbumin-Induced Anaphylaxis Mode…

Kang(YM),Shim(KS),Chae(SW),Bok(SH),Park(DH),… Biomol Ther (Seoul) 2025-07-01

...Syk) in the FcεRI signaling pathway in BMMCs. Furthermore, curcumenol suppressed the activation of Akt, PLCγ1, and mitog...

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