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Novosphingobium aromaticivorans uses a Nu-class glutathione S-transferase as a …

Kontur(WS),Bingman(CA),Olmsted(CN),Wassarman… J Biol Chem 2018-00-06

...SYK-6 (which can also break the β-aryl ether bond) and Escherichia coli (which cannot break the β-aryl ether bond) can a...

Tyrosine Kinase Inhibitor Pazopanib Inhibits Platelet Procoagulant Activity in …

Tullemans(BME),Nagy(M),Sabrkhany(S),Griffioe… Front Cardiovasc Med 2018-00-00

...Syk. Furthermore, pazopanib inhibited GPVI-induced Ca2+ elevation, resulting in reduced exposure of the procoagulant pho...

Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix …

Kjelgaard-Petersen(CF),Sharma(N),Kayed(A),Ka… Biochem Pharmacol 2019-00-00

...Syk) inhibitor), TPCA-1 (Inhibitor of κB kinase (Ikk) inhibitor), or Tofacitinib (Tofa) (Janus kinases (Jak) inhibitor)....

Comprehensive Analysis of Clinical and Molecular Features in Cancer Patients As…

Mohamed(AO),Long(R),He(Y),Wang(X) J Med Virol 2025-02-00

...Syk were upregulated in HPV+ HNSC and EBV+ STAD, and positively correlated with the enrichment levels of CD8 + T cell, P...

Mast Cell Activation and Microtubule Organization Are Modulated by Miltefosine …

Rubíková(Z),Sulimenko(V),Paulenda(T),Dráber(… Front Immunol 2018-00-00

...Syk kinases, and Ca2+ influx were not inhibited. In contrast, lipid raft disruptor methyl-β-cyclodextrin attenuated the ...

Platelet Responses After Tapering and Discontinuation of Fostamatinib in Patien…

Mingot-Castellano(ME),García-Donas(G),Campos… J Clin Med 2024-10-22

...SYK) inhibitor approved for the treatment of adult patients with chronic immune thrombocytopenia (ITP). There is little ...

Application of a phenotypic drug discovery strategy to identify biological and …

Orellana(A),García-González(V),López(R),Pasc… PLoS One 2018-00-00

...Syk kinase did not seem to be related. Overall, inhibition of TSLP production by the selected hits, rather than resultin...

Decoding microglial immunometabolism: a new frontier in Alzheimer's disease res…

Jung(ES),Choi(H),Mook-Jung(I) Mol Neurodegener 2025-03-27

...Syk, which influences immune responses and Aβ clearance. These insights offer promising therapeutic targets, including s...

Rapid Characterization of Chemical Components in Edible Mushroom Sparassis cris…

Wang(Z),Liu(J),Zhong(X),Li(J),Wang(X),Ji(L),… Molecules 2019-08-20

...Syk as receptors, followed by the anti-inflammatory activity evaluation for screened hits by intracellular calcium mobil...

The Direct Thrombin Inhibitors Dabigatran and Lepirudin Inhibit GPIbα-Mediated …

Trabold(K),Makhoul(S),Gambaryan(S),van Ryn(J… Thromb Haemost 2019-06-00

...Syk Y352 phosphorylation (used here as readout for an early signal occurring during echicetin-induced platelet aggregati...

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