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Impaired integrin-mediated signal transduction, altered cytoskeletal structure …

Suen(PW),Ilic(D),Caveggion(E),Berton(G),Dams… J Cell Sci 1999-11-00

...Syk and Pyk2 tyrosine kinases, were all significantly reduced in double mutant cells. The subcellular localization of fo...

Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor z…

Enyedy(EJ),Nambiar(MP),Liossis(SN),Dennis(G)… Arthritis Rheum 2001-05-00

...Syk and the CD3epsilon chain, suggesting that FcepsilonRIgamma is functionally involved in TCR signaling. These results ...

A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice.

Hasegawa(M),Fujimoto(M),Poe(JC),Steeber(DA),… J Immunol 2001-09-01

...Syk phosphorylation was normal. In addition, the enhanced intracellular Ca(2+) responses following B cell Ag receptor li...

Calphostin C triggers calcium-dependent apoptosis in human acute lymphoblastic …

Zhu(DM),Narla(RK),Fang(WH),Chia(NC),Uckun(FM) Clin Cancer Res 1998-12-00

...syk, btk, PLCgamma2, or IP3R genes does not prevent or attenuate its cytotoxicity. In our study, calphostin C also induc...

Vav family proteins couple to diverse cell surface receptors.

Moores(SL),Selfors(LM),Fredericks(J),Breit(T… Mol Cell Biol 2000-09-00

...Syk was also expressed, suggesting that integrin activation of Vav proteins may be restricted to cell types that express...

Tyrosine kinase-dependent assembly of actin plaques linking Fc epsilon R1 cross…

Pfeiffer(JR),Oliver(JM) J Immunol 1994-01-01

...Syk and Lyn, and elicits secretion and F-actin assembly, membrane ruffling, and increased spreading and adhesion. Herein...

Chronic PMA treatment of Jurkat T lymphocytes results in decreased protein tyro…

Ahnadi(CE),Giguère(P),Gravel(S),Gagné(D),Gou… J Leukoc Biol 2000-08-00

...syk families. The electrophoretic mobilities of p59(fyn) or ZAP-70 were not changed in PMA-treated cells but p56(Ick) mi...

Sequential activation of different Ca2+ entry pathways upon cholinergic stimula…

Camello(C),Pariente(JA),Salido(GM),Camello(P… J Physiol 1999-04-15

...Syk tyrosine kinase, inhibited CCE during ACh decay but not during Ca2+ reintroduction. 3. Simultaneous detection of Mn2...

CRP promotes monocyte-endothelial cell adhesion via Fcgamma receptors in human …

Devaraj(S),Davis(B),Simon(SI),Jialal(I) Am J Physiol Heart Circ Physi… 2006-09-00

...Syk kinase inhibitor piceatannol and MG-132, a proteasome degradation inhibitor, produced similar attenuation in NF-kapp...

Potent anti-inflammatory effects of the narrow spectrum kinase inhibitor RV1088…

To(Wing S),Aungier(Susan R),Cartwright(Aliso… Br J Pharmacol 2016-05-31

...Syk), is more effective at inhibiting inflammatory signalling in rheumatoid arthritis (RA) than single kinase inhibitors...

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