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Megakaryocytes Internalize and Are Activated by Immune Complexes.

Puhm(F),Allaeys(I),Petito(E),Sang(Y),Tupin(F… Circ Res 2026-07-17

...Syk (spleen tyrosine kinase) signaling, and protein translation. A detailed analysis revealed that megakaryocyte-derived...

Protective Effects of the Ethanolic Leaf Extract of Ocimum sanctum L. on Collag…

Maaz(M),Balupillai(A),Periyakali(S),Padhan(J… Molecules 2026-08-07

...SYK, PLCγ2, P2RY12, and PI3Kβ. Some phytoconstituents showed good binding affinities, with apigenin having the highest b...

Decoding TREM2: A microglial receptor governing the fate of myelin.

Zhang(Z),Zhang(W),Jin(L),Wei(C),Chen(H),Chen… Cell Signal 2026-08-13

...SYK)-phosphatidylinositol 3-kinase (PI3K), phospholipase C gamma 2 (PLCγ2), beta-catenin and transcription factor EB (TF...

Unveiling the gut-brain axis: How chronic exposure to arsenic-induced microglia…

Qu(J),Jiang(X),Ma(Y),Sheng(X),Pi(C),Wang(Y),… J Hazard Mater 2026-02-01

...SYK and CD36). Furthermore, SiAhR treatment could alleviated microglial inflammatory injury and enhancing the microglia'...

Esculetin mitigates mast cell-mediated allergic inflammation and anaphylaxis by…

Kim(D),Yoon(J),Jeong(NH),Choi(YA),Jin(M),Lee… Inflammopharmacology 2026-02-00

...Syk, ultimately reducing intracellular calcium influx. CONCLUSION: These findings suggest that esculetin may serve as a ...

Identification and computational assessment of novel targeting sites of dexamet…

Dwivedi(SD),Rathor(LS),Singh(D),Singh(MR) In Silico Pharmacol None

...Syk), Interferon (IFN)-γ, Nicotinamide phosphoribosyl transferase (NAMPT) or Visfatin, NF-κB receptors which are respons...

Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2, a…

Martin(EM),Clark(JC),Montague(SJ),Morán(LA),… J Thromb Haemost 2024-00-00

...Syk. PEAR1 signals through a YxxM motif that activates phosphoinositide 3-kinase. Current ligands for these receptors ha...

Rituximab Binding Endows CD20+ Extracellular Vesicles With NK Cell-Activating P…

Otero(AV),Pérez(PS),Gaete-Ramírez(B),Cordini… J Extracell Vesicles 2026-08-00

...Syk phosphorylation, CD69 expression, and enhanced lytic activity against target cells. Our findings uncover a previousl...

A Tetrahydrofolate-Dependent Methyltransferase Catalyzing the Demethylation of …

Yao(Li),Yu(Lin-Lu),Zhang(Jun-Jie),Xie(Xiang-… Appl Environ Microbiol 0000-00-00

...SYK-6, respectively. The purified Dmt catalyzed the transfer of methyl from dicamba to THF to form the herbicidally inac...

The role of organ-deposited IgG in the pathogenesis of multi-organ and tissue d…

Qiu(W),Yu(T),Deng(GM) Front Immunol 2022-00-00

...Syk) inhibitors, which can block the signaling transduction of IgG/Fc gamma receptors (FcγRs), can prevent and treat ski...

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