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Deletion of Alzheimer's disease-associated CD33 results in an inflammatory huma…

Wißfeld(J),Nozaki(I),Mathews(M),Raschka(T),E… Glia 2021-00-00

...SYK) and extracellular signal-regulated kinase 1 and 2 (ERK1 and 2). Transcript analysis by quantitative real-time polym...

Sovleplenib (HMPL-523), a novel Syk inhibitor, for patients with primary immune…

Liu(X),Zhou(H),Hu(Y),Yin(J),Li(J),Chen(W),Hu… Lancet Haematol 2023-06-00

...Syk) inhibitor is a treatment option for primary immune thrombocytopenia. We aimed to evaluate the safety, tolerability,...

Molecular mechanisms of neutrophil regulatory network in anti-Candida infection.

Xu(Y),Cheng(R),Li(W),Yu(W),Chen(C) Front Immunol 2025-00-00

...SYK)-phosphoinositide 3-kinase (PI3K)-extracellular signal-regulated kinase (ERK) pathways and drives microtubule-associ...

Identification of histone methyltransferase NSD2 as an important oncogenic gene…

Zhao(LH),Li(Q),Huang(ZJ),Sun(MX),Lu(JJ),Zhan… Cell Death Dis 2021-00-20

...SYK, and MET) and Akt activation were significantly decreased after NSD2 silencing or knockout in primary colon cancer c...

Regulation of outside-in signaling in platelets by integrin-associated protein …

Buensuceso(CS),Obergfell(A),Soriani(A),Eto(K… J Biol Chem 2005-01-07

...Syk. Therefore, we asked whether alpha(IIb)beta(3) might also interact with PKC. Of the several PKC isoforms expressed i...

Inhibition of the antigen-induced activation of rodent mast cells by putative J…

Linwong(W),Hirasawa(N),Aoyama(S),Hamada(H),S… Br J Pharmacol 2005-07-00

...Syk inhibitor WHI-P154 (4-(3'-bromo-4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline) on the antigen-induced activation ...

The role of CD150-SH2D1A association in CD150 signaling in Hodgkin's lymphoma c…

Yurchenko(MY),Kashuba(EV),Shlapatska(LM),Siv… Exp Oncol 2005-03-00

...Syk, Lyn, SHP-2, SHIP proteins, and activated/phosphorylated ERK1/2 and Akt proteins were detected by Western blot analy...

A non-XLA primary deficiency causes the earliest known defect of B cell differe…

Meffre(E),LeDeist(F),de Saint-Basile(G),Devi… Immunol Lett 1997-06-01

...Syk, Pax-5, CD19, Ig alpha, Ig beta, VH-C mu and V kappa-C kappa transcripts characteristic of later stages were severel...

CD84 negatively regulates IgE high-affinity receptor signaling in human mast ce…

Álvarez-Errico(D),Oliver-Vila(I),Ainsua-Enri… J Immunol 2011-12-01

...Syk-linker for activation of T cells-phospholipase C-γ1 axis activity is downregulated after CD84 stimulation, compared ...

Regulation of Src family tyrosine kinase activities in adherent human neutrophi…

Yan(SR),Berton(G) J Biol Chem 1996-09-20

...syk) was not affected by catalase in normal neutrophils, and it was comparable in normal and CGD neutrophils. These find...

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