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Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer …

Martin(P),Gillen(M),Millson(D),Oliver(S),Bre… Drugs R D 2016-03-00

...SYK) inhibitor. The active metabolite of fostamatinib, R406, is primarily metabolized by CYP3A4. The aim of this study w...

Restoration of aberrant gene expression of monocytes in systemic lupus erythema…

Nikolakis(D),Garantziotis(P),Sentis(G),Fanou… BMC Genomics 2023-04-18

...SYK kinase inhibitors. Furthermore, according to our network-based drug repurposing approach, an IL-12/23 inhibitor and ...

Aberrant B cell receptor signaling in circulating naïve and IgA+ memory B cells…

Neys(SFH),Heutz(JW),van Hulst(JAC),Vink(M),B… J Autoimmun 2024-00-00

...SYK and BTK protein expression, and IgA and IgG anti-citrullinated protein antibody concentrations in serum from autoant...

Expression profiling of Sudanese visceral leishmaniasis patients pre- and post-…

Salih(MAM),Fakiola(M),Lyons(PA),Younis(BM),M… Parasite Immunol 2017-06-00

...SYK, RUNX2, MMP1 and ACTA2. Top endogenous upstream regulators included IL-7 (P=2.28×10-6 ), TNF (P=4.26×10-6 ), Amyloid...

Molecular mechanisms of breast cancer metastasis by gene expression profile ana…

Zheng(T),Wang(A),Hu(D),Wang(Y) Mol Med Rep 2017-10-00

...SYK), respectively. Several genes crucial in the metastasis of breast cancer were identified, which may serve as potenti...

Using machine learning to dissect host kinases required for Leishmania internal…

Wei(L),Barrie(U),Aloisio(GM),Khuong(FTH),Ara… Mol Biochem Parasitol 2024-00-00

...SYK)), but we also uncovered many novel kinases. Our methods also predicted host kinases necessary for promastigotes to ...

The bacterial meta-cleavage hydrolase LigY belongs to the amidohydrolase superf…

Kuatsjah(E),Chan(ACK),Kobylarz(MJ),Murphy(ME… J Biol Chem 2017-00-03

...SYK-6 of the bacterium Sphingobium sp. catabolizes lignin-derived biphenyl via a meta-cleavage pathway. In this pathway,...

Screening and validation of differentially expressed extracellular miRNAs in ac…

Meng(S),Wang(H),Xue(D),Zhang(W) Mol Med Rep 2017-11-00

...Syk, Lhcgr, Slc9a3r1, Cacnb1, Cacna1b, Bcl10, and Fgd3. Functional enrichment analysis revealed that the main GO‑BP pred...

Transcriptome analysis reveals PRKCA as a potential therapeutic target for over…

Sun(T),Zhang(P),Zhang(Q),Wang(B),Zhao(Q),Liu… Heliyon 2024-05-30

...Syk. The in vitro experiments revealed that PRKCA was upregulated in the cisplatin-resistant A549 cells (DDP-A549), whil...

Using machine learning to dissect host kinases required for Leishmania internal…

Wei(L),Barrie(U),Aloisio(GM),Khuong(FTH),Ara… bioRxiv 2024-08-04

...SYK)), but we also uncovered many novel kinases. Our methods also predicted host kinases necessary for promastigotes to ...

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