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Sequestration and inhibition of Daxx-mediated transcriptional repression by PML.

Li(H),Leo(C),Zhu(J),Wu(X),O'Neil(J),Park(E... Mol Cell Biol 2000-03-16

...Daxx to the PODs and for efficient inhibition of Daxx-mediated transcriptional repression. Consistently, Daxx is found a...

Role of SUMO-1-modified PML in nuclear body formation.

Zhong(S),Müller(S),Ronchetti(S),Freemont(P... Blood 2000-05-23

...Daxx, and SUMO-1 fail to accumulate in the NB and acquire aberrant localization patterns. Transfection of PML in PML(-/-...

Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains...

Torii(S),Egan(D A),Evans(R A),Reed(J C) EMBO J 2000-01-04

...Daxx (hDaxx) display enhanced sensitivity to apoptosis induced by Fas but not by several other cell death stimuli. hDaxx...

Dissecting Fas signaling with an altered-specificity death-domain mutant: req...

Chang(H Y),Yang(X),Baltimore(D) Proc Natl Acad Sci U S A 1999-03-25

...Daxx, which couples Fas to the Jun N-terminal kinase pathway, bind independently to the Fas death domain. We have isolat...

PML is critical for ND10 formation and recruits the PML-interacting protein d...

Ishov(A M),Sotnikov(A G),Negorev(D),Vladim... J Cell Biol 1999-11-17

...Daxx and PML. The segregation of Daxx from condensed chromatin in the absence of PML to ND10 by increased accumulation o...

The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hD...

Hollenbach(A D),Sublett(J E),McPherson(C J... EMBO J 1999-08-31

...Daxx (hDaxx) interacts with Pax3 in vivo and with DNA-bound Pax3 in vitro. This interaction is mediated primarily throug...

Loss of Daxx, a promiscuously interacting protein, results in extensive apopt...

Michaelson(J S),Bader(D),Kuo(F),Kozak(C),L... Genes Dev 1999-09-07

...Daxx's physiologic function remains unknown. To elucidate the in vivo role of Daxx, we have generated Daxx-deficient mic...

Modulation of life and death by the TNF receptor superfamily.

Baker(S J),Reddy(E P) Oncogene 1999-02-16

...DAXX have provided new insights to our understanding of signaling mechanisms associated with this family of receptors. W...

Cloning and expression of primate Daxx cDNAs and mapping of the human gene to...

Kiriakidou(M),Driscoll(D A),Lopez-Guisa(J ... DNA Cell Biol 1998-01-06

...Daxx cDNAs, the widespread expression of Daxx mRNA in human tissues, and the mapping of the human Daxx gene to 6p21.3 in...

Fas-mediated apoptosis and activation-induced T-cell proliferation are defect...

Zhang(J),Cado(D),Chen(A),Kabra(N H),Winoto(A) Nature 1998-04-06

...Daxx, also bind Fas and presumably mediate a FADD-independent apoptotic pathway. Here we investigate the role of FADD in...

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