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Rehmannia Glutinosa Pharmacopuncture Solution Regulates Functional Activation, …

Kang(Kyung-Hwa),Lee(Kyung-Hee),Yoon(Hyun-Min… J Pharmacopuncture 2015-03-17

...Syk, LAT, Gab2, PLC γ1/2, PI3K, Akt, cPLA2 and IκBα.,RGPS effectively suppresses mast cell activations such as degranula...

Distinct pathways regulate Syk protein activation downstream of immune tyrosine…

Manne(Bhanu Kanth),Badolia(Rachit),Dangelmai… J Biol Chem 2015-07-16

...Syk are not completely understood. In this study, we identified a novel signaling mechanism in CLEC-2-mediated Syk activ...

Targeting Syk-activated B cells in murine and human chronic graft-versus-host d…

Flynn(Ryan),Allen(Jessica L),Luznik(Leo),Mac… Blood 2015-09-04

...Syk was necessary in donor B cells, but not T cells, for disease progression. Bone marrow-specific Syk deletion in vivo ...

Inhibition of osteoclast activation by phloretin through disturbing αvβ3 integr…

Lee(Eun-Jung),Kim(Jung-Lye),Gong(Ju-Hyun),Pa… Biomed Res Int 2015-12-15

...Syk phosphorylation and phospholipase Cγ induction by RANKL in osteoclasts. These results suggest that phloretin was an ...

Substrate stiffness regulates B-cell activation, proliferation, class switch, a…

Zeng(Yingyue),Yi(Junyang),Wan(Zhengpeng),Liu… Eur J Immunol 2015-08-18

...Syk molecules compared with antigens on softer substrates. In vitro expansion of mouse primary B cells shows different p...

LEADOPT: an automatic tool for structure-based lead optimization, and its appli…

Li(Guo-Bo),Ji(Sen),Yang(Ling-Ling),Zhang(Ron… Eur J Med Chem 2015-12-21

...SYK inhibitor, R406. Though just several compounds were synthesized, we have obtained some compounds that are more poten...

Expression of dectin-1 and enhanced activation of NALP3 inflammasome are associ…

Feriotti(Claudia),Bazan(Silvia B),Loures(Flá… Front Microbiol 2015-09-21

...Syk kinase phosphorylation and expression of intracellular pro-IL-1β than B10.A cells. These findings led us to investig...

AAL exacerbates pro-inflammatory response in macrophages by regulating Mincle/S…

Zhang(Zhijun),He(Long),Hu(Shuang),Wang(Yi),L… Am J Transl Res 2015-12-22

...Syk/Card9 signaling, which then couples to the Nlrp3 inflammasome assembly. It was further noted that AAL markedly promo...

[MORPHOFUNCTIONAL STATE OF BLOOD CELLS AFTER CHRONIC EXPOSURE OF THE PROTEIN KI…

Byelinska(I V),Lynchak(O V),Tsyvinska(S M),R… Fiziol Zh 2015-11-24

...Syk(h), YES, ZAP70 et al. with antineoplastic activity, on blood cells parameters of rats after chronic exposure has bee...

Alchemical FEP Calculations of Ligand Conformer Focusing in Explicit Solvent.

Zeifman(Alexey A),Stroylov(Victor V),Novikov… J Chem Theory Comput 2015-11-24

...Syk inhibitors and significantly improved the resulting accuracy of predictions.

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