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Peptide ligand structure and I-Aq binding avidity influence T cell signaling pa…

Myers(Linda K),Cullins(David L),Park(Jeoung-… Clin Immunol 2015-12-15

...Syk. However, it remains unknown whether the affinity of peptide binding to MHC drives this selection. To answer this qu...

Fisetin Suppresses Macrophage-Mediated Inflammatory Responses by Blockade of Sr…

Kim(Jun Ho),Kim(Mi-Yeon),Kim(Jong-Hoon),Cho(… Biomol Ther (Seoul) 2015-09-04

...Syk, and IκBα, were also reduced by fisetin. The phospho-Src level, triggered by overexpression of wild-type Src, was al...

[Treatment Progress of Immune Thrombocytopenia].

Wu(Bing),Wei(Yan),Zhang(Qian) Zhongguo Shi Yan Xue Ye Xue Z… 2015-11-23

...Syk (spleen tyrosine kinase) inhibitor, can target at certain key steps in the disease process, showing the potential to...

Harpagoside Inhibits RANKL-Induced Osteoclastogenesis via Syk-Btk-PLCγ2-Ca(2+) …

Kim(Ju-Young),Park(Sun-Hyang),Baek(Jong Min)… J Nat Prod 2015-12-22

...Syk-Btk-PLCγ2-Ca(2+) in RANKL-dependent early signaling, as well as the activation of c-Fos and nuclear factor of activa...

Analysis of the anti-proliferative and the pro-apoptotic efficacy of Syk inhibi…

Koerber(Ruth-Miriam),Held(Stefanie Andrea Er… Exp Hematol Oncol 2015-08-07

...Syk as a target in MM.,The MM cell lines AMO-1, U266 and RPMI8226 and primary MM cells were treated with the Syk inhibit...

Spleen Tyrosine Kinase Confers Paclitaxel Resistance in Ovarian Cancer.

Wei(Wei),Birrer(Michael J) Cancer Cell 2015-10-14

...SYK) in paclitaxel resistance by modulating the stability of microtubules.

20(S)-Protopanaxatriol inhibits release of inflammatory mediators in immunoglob…

Kim(Dae Yong),Ro(Jai Youl),Lee(Chang Ho) J Ginseng Res 2015-07-22

...Syk protein, cytokine mRNA, cyclooxygenase-1/2, and phospholipase A2 (PLA2), as well as the activities of various protei...

Fibrin activates GPVI in human and mouse platelets.

Alshehri(Osama M),Hughes(Craig E),Montague(S… Blood 2015-12-21

...Syk, in human and mouse platelets induced by thrombin in the presence of fibrinogen and the αIIbβ3 blocker eptifibatide....

Stromal CYR61 Confers Resistance to Mitoxantrone via Spleen Tyrosine Kinase Act…

Long(Xin),Yu(Yang),Perlaky(Laszlo),Man(Tsz-K… Br J Haematol 2015-10-26

...SYK) mediates CYR61 signalling. Exposure to stroma increased SYK expression and activation in AML cells, and this increa...

Computational and in vitro Investigation of miRNA-Gene Regulations in Retinobla…

Venkatesan(Nalini),Deepa(Perinkulam Ravi),Kh… Bioinform Biol Insights 2015-05-18

...SYK, FASN); Group 2: cancer stem cell markers (TACSTD, ABCG2, CD133, CD44, CD24) and Group 3: cell cycle regulatory prot...

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