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Macrophage autophagy protects against acute kidney injury by inhibiting renal i…

Huang(XR),Ye(L),An(N),Wu(CY),Wu(HL),Li(HY),H… Autophagy 2025-00-00

...SYK, spleen tyrosine kinase; TARM1, T cell-interacting, activating receptor on myeloid cells 1; TAX1BP1, Tax1 (human T c...

Efficacy and safety of sovleplenib (HMPL-523) in adult patients with chronic pr…

Hu(Y),Liu(X),Zhou(H),Wang(S),Huang(R),Wang(Y… Lancet Haematol 2024-08-00

...SYK) inhibitor, showed promising safety and activity in patients with primary immune thrombocytopenia in a phase 1b/2 tr...

Network-Based Meta-Analyses of Associations of Multiple Gene Expression Profile…

He(Hao),Cao(Shaolong),Niu(Tianhua),Zhou(Yu),… PLoS One 2016-07-08

...SYK) were identified based on gene expression meta-analysis, and their associations with BMD were also replicated by two...

Daphnetin contributes to allergen-induced Th2 cytokine expression and type 2-im…

Zhang(Y),Qu(L),Sun(Y),Lin(Y),Zeng(J),He(L),L… Food Funct 2022-11-28

...syk in the RBL-2H3 cells. Therefore, Dap. can be represented as a potential therapeutic strategy for the treatment of al...

Leveraging ADMET Profiling, Network Pharmacology, and Molecular Docking to Eval…

Ugbaja(SC),Nkabinde(SA),Nkabinde(M),Gqaleni(… Biomedicines 2026-04-30

...SYK pathways. These results necessitate further experimental and clinical validation, providing a solid computational ba...

Identifcation of the FGF family as therapeutic targets and prognostic biomarker…

Zhang(L),Gao(Y),Tian(Y),Wei(J),Xu(Y),Zhang(X… SLAS Technol 2025-06-00

...SYK, LCK, HCK, PKN2, RPS6KA1, BUB1, CDK5, ITK, FYN, TBK1, ATM, CDK2, PTK2 are kinase targets of the FGF family. We ident...

Cartilage oligomeric matrix protein acts as a molecular biomarker in multiple c…

Guo(B),Wang(Y),Liu(W),Zhang(S) Clin Transl Oncol 2023-02-00

...SYK. Finally, we verified the function of COMP at the cellular level by using J82 and T24 cells and found that knockdown...

Glial Cells in the Early Stages of Neurodegeneration: Pathogenesis and Therapeu…

Ahremenko(E),Andreev(A),Apushkin(D),Korkotia… Int J Mol Sci 2025-12-12

...SYK)/ DNAX-activating protein 10 (DAP10), siglec-3 (CD33), chemokine C-X3-C motif ligand 1/ CX3C motif chemokine recepto...

Soluble HLA class I molecules/CD8 ligation trigger apoptosis of CD8+ cells by F…

Puppo(F),Contini(P),Ghio(M),Indiveri(F) ScientificWorldJournal 2002-02-12

...syk-like ZAP-70 PTK and protein kinase C, and extracellular calcium influx. Then, activation and nuclear translocation o...

Impaired lipophagy induced-microglial lipid droplets accumulation contributes t…

Li(Q),Zhao(Y),Guo(H),Li(Q),Yan(C),Li(Y),He(S… Autophagy 2023-00-00

...SYK: spleen asociated tyrosine kinase; SYP: synaptophysin; T2DM: type 2 diabetes mellitus; TNF/TNF-α: tumor necrosis fac...

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