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Protein tyrosine phosphatase SAP-1 protects against colitis through regulation …

Murata(Yoji),Kotani(Takenori),Supriatna(Yana… Proc Natl Acad Sci U S A 2015-11-17

...Syk) promoted the production of IL-8 in cultured cells through the activation of nuclear factor-κB (NF-κB). In addition,...

Contribution of MINCLE-SYK Signaling to Activation of Primary Human APCs by Myc…

Ostrop(Jenny),Jozefowski(Katrin),Zimmermann(… J Immunol 2015-12-15

...Syk-Card9 pathway. However, it is unknown whether these glycolipids activate human innate immune cells through the same ...

AAL exacerbates pro-inflammatory response in macrophages by regulating Mincle/S…

Zhang(Zhijun),He(Long),Hu(Shuang),Wang(Yi),L… Am J Transl Res 2015-12-22

...Syk/Card9 signaling, which then couples to the Nlrp3 inflammasome assembly. It was further noted that AAL markedly promo...

Disturbed T Cell Signaling and Altered Th17 and Regulatory T Cell Subsets in th…

Rother(Nils),van der Vlag(Johan) Front Immunol 2015-12-09

...Syk kinase, and calcium signaling molecules have been associated with SLE, which leads to hyperresponsive autoreactive T...

Alchemical FEP Calculations of Ligand Conformer Focusing in Explicit Solvent.

Zeifman(Alexey A),Stroylov(Victor V),Novikov… J Chem Theory Comput 2015-11-24

...Syk inhibitors and significantly improved the resulting accuracy of predictions.

[MORPHOFUNCTIONAL STATE OF BLOOD CELLS AFTER CHRONIC EXPOSURE OF THE PROTEIN KI…

Byelinska(I V),Lynchak(O V),Tsyvinska(S M),R… Fiziol Zh 2015-11-24

...Syk(h), YES, ZAP70 et al. with antineoplastic activity, on blood cells parameters of rats after chronic exposure has bee...

CLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but …

Borgognone(A),Navarro-Núñez(L),Correia(J N),… J Thromb Haemost 2015-02-24

...Syk and PLCγ2. In contrast, adhesion and spreading of platelets on recombinant podoplanin, CLEC-2 antibody and LECs is n...

Kinase inhibitors: the next generation of therapies in the treatment of rheumat…

MacFarlane(Lindsey A),Todd(Derrick J) Int J Rheum Dis 2015-01-12

...Syk). This review article summarizes the evidence supporting the use of various kinase inhibitors, including the newly a...

Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cel…

Morrison(Vicky Louise),James(Martyn John),Gr… Nat Commun 2015-10-20

...Syk signalling, and to the induction of a transcriptional programme characteristic of mature, migratory dendritic cells,...

New spleen tyrosine kinase inhibitors: patent applications published during 201…

Thorarensen(Atli),Kaila(Neelu) Pharm Pat Anal 2015-06-29

Spleen tyrosine kinase (SYK) is one of the more advanced small-molecule targets with regard to clinical development for ...

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