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Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated …

Pollitt(Alice Y),Poulter(Natalie S),Gitz(Eel… J Biol Chem 2015-04-14

...Syk tyrosine kinases promotes platelet adhesion to primary mouse lymphatic endothelial cells at low shear. Using support...

SYK is a candidate kinase target for the treatment of advanced prostate cancer.

Ghotra(Veerander P S),He(Shuning),van der Ho… Cancer Res 2015-04-23

...SYK expression. In the absence of SYK expression, cell surface levels of the progression-associated adhesion receptors i...

Inhibitors of BCR signalling interrupt the survival signal mediated by the micr…

Bernard(Sophie),Danglade(Damien),Gardano(Lau… Int J Cancer 2015-06-22

...SYK, respectively. Our study addresses survival signals emanating from the BCR or the tumour environment and how inhibit...

Tumor progression locus 2-dependent oxidative burst drives phosphorylation of e…

Kuriakose(Teneema),Rada(Balázs),Watford(Wend… J Biol Chem 2015-04-14

...Syk. Signals from TLRs 3 and 9 do not initiate early activation of IKKβ-Tpl2-ERK pathway but instead induce delayed, NAD...

HGAL localization to cell membrane regulates B-cell receptor signaling.

Lu(Xiaoqing),Sicard(Renaud),Jiang(Xiaoyu),St… Blood 2015-03-24

...Syk kinase activity and activation of its downstream effectors. Herein we demonstrate that HGAL protein can be myristoyl...

Suboptimal B-cell antigen receptor signaling activity in vivo elicits germinal …

Königsberger(Sebastian),Weis(Vanessa),Prodöh… Eur J Immunol 2015-04-13

...Syk kinase loss in the presence of a Zap-70 knock-in rescue allele. Cre-mediated Syk deletion in Syk(flox/Zap-70) B cell...

The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, s…

Hughes(Craig E),Finney(Brenda A),Koentgen(Fr… Blood 2015-03-13

...Syk on platelet activation by GPVI, CLEC-2, and integrin αIIbβ3. The Syk(R41Afl/fl) mouse was crossed to a PF4-Cre(+) mo...

Expression of B-cell-associated genes in peripheral blood mononuclear cells of …

Lv(Wei),Duan(Qianglin),Wang(Lemin),Gong(Zhu)… Mol Med Rep 2015-10-15

...SYK, BTK, PTPRC and NFAM1, whereas expression levels of FYN, FCRL4 and LAX1 were significantly decreased compared to tho...

An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulat…

Yasukawa(Shinsuke),Miyazaki(Yoshiyuki),Yoshi… Nat Commun 2015-08-04

...Syk or NLRP3, but not MyD88, is sufficient to abolish CHS. All tested haptens, but not irritants, can induce Syk activat...

IgE regulates the expression of smMLCK in human airway smooth muscle cells.

Balhara(Jyoti),Redhu(Naresh Singh),Shan(Lian… PLoS One 2015-01-15

...Syk knock down and pharmacological inhibition of mitogen activated protein kinases (MAPK) (ERK1/2, p38, and JNK) and pho...

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