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ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-hydr…

Kotla(Sivareddy),Singh(Nikhlesh K),Traylor(J… Free Radic Biol Med 2015-08-25

...Syk and Pyk2-dependent STAT1 activation. In line with these observations, 15(S)-HETE also induced foam cell formation in...

Insight into the therapeutic aspects of 'Zeta-Chain Associated Protein Kinase 7…

Kaur(Maninder),Singh(Manjinder),Silakari(Om) Cell Signal 2015-05-15

...Syk family (non-receptor protein tyrosine kinase family), has an imperative function in the immune cell signaling in T c...

Functional roles of Syk in macrophage-mediated inflammatory responses.

Yi(Young-Su),Son(Young-Jin),Ryou(Chongsuk),S… Mediators Inflamm 2015-02-12

...Syk is also involved in other biological functions, especially in innate immune responses. Although Syk has been extensi...

Phagocytic cells internalize ZnO particles by FcγII/III-receptor pathway.

Roy(Ruchi),Chauhan(L K S),Das(Mukul),Tripath… Immunobiology 2015-04-13

...Syk (spleen tyrosine kinase), p-PLC-γ and PI3K (phosphatidylinositol 3-kinase). Our findings illustrate that the phagocy...

B-cell receptor signalling and its crosstalk with other pathways in normal and …

Seda(Vaclav),Mraz(Marek) Eur J Haematol 2015-11-12

...SYK, BTK, PI3K) have an encouraging clinical effect. Here we describe the current knowledge of the specific aspects of B...

The active metabolite of spleen tyrosine kinase inhibitor fostamatinib abrogate…

Platt(Andrew M),Benson(Robert A),McQueenie(R… Rheumatology (Oxford) 2015-03-26

Spleen tyrosine kinase (SYK) is a core signalling protein that drives inflammatory responses and is fundamental to the p...

Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates a…

Ben Mkaddem(Sanae),Hayem(Gilles),Jönsson(Fri… J Clin Invest 2015-01-20

...SYK and tyrosine phosphatase SHP-1. Anti-hFcγRII F(ab')2 treatment of inflammatory synovial cells from RA patients inhib...

Syk signaling in dendritic cells orchestrates innate resistance to systemic fun…

Whitney(Paul G),Bär(Eva),Osorio(Fabiola),Rog… PLoS Pathog 2015-11-06

Host protection from fungal infection is thought to ensue in part from the activity of Syk-coupled C-type lectin recepto...

Integration of genomic information in development of pharmacological vascular d…

Baskys(Andrius) J Alzheimers Dis 2015-06-29

...SYK, AGT, and RPGRIP1L. Genes that were upregulated in VaD were MMP9 and VEGFA. TNFSF14, AR, and PHLDB2 were also associ...

Prospection of genomic regions divergently selected in racing line of Quarter H…

Meira(C T),Curi(R A),Farah(M M),de Oliveira(… Animal 2015-05-27

...SYK, ANG, CNTFR and HTR2B.

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