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Recombinant cathepsins B and L promote α-synuclein clearance and restore lyso...

Balta(D),Varghese(A),Prieto Huarcaya(S),Di... Mol Neurodegener 2025-08-29

...CTSL regarding SNCA degradation by dosing recombinant human procathepsin B (rHsCTSB) and procathepsin L (rHsCTSL) alone ...

HIFU-Driven Targeted Pyroptosis Therapy in Basal-Like Breast Cancer.

Su(X),Wang(Y),Qin(X),Xiao(Y),Ouyang(B),Hu(... Adv Sci (Weinh) 2025-11-00

...CTSL) gene transcription. Simultaneously, Plp and HIFU synergistically suppressed BCL-2 via CTSL, increasing ROS product...

Targeting lysosomal protease CTSL promotes anti-tumor immunity and sensitizes...

Ding(Y),Zhang(H),Wang(X),Tan(J),Wang(M),Ch... Neoplasia 2025-11-00

...CTSL as a key driver of PD-L1-dependent immune evasion through the CTSL-PDK1-AKT axis and highlight CTSL inhibition as a...

Altered amyloid plasma profile in patients with disabling headaches after SAR...

Aamodt(AH),Ueland(T),Boldingh(M),Bezgal(BE... BMJ Neurol Open 2025-00-00

...CTSL) and serum Amyloid A (SAA1) were measured using ELISA and compared with levels in healthy controls (n=16). We found...

Construction of a Core Germplasm and Identification of Candidate SNPs Associa...

Cao(L),Ma(J),Hong(N),Yao(J),Lu(Y),Wu(Y),Ta... Mar Biotechnol (NY) 2025-09-10

...CTSL, OTOF, and nestin, and were involved in cell development, differentiation and proliferation, glycolytic metabolism,...

Repurposing a Detrimental Antibody Epitope as Targeted Therapeutics for Sepsi...

Chen(W),Lou(L),Qiang(X),Zhu(CS),Li(J),Chen... Res Sq 2025-09-19

...Ctsl mRNA upregulation and procathepsin L (pCTS-L) secretion from human immune cells, crucially without perturbing other...

Unveiling the molecular mechanisms of hemorrhagic shock and acute lung injury...

Mishra(M),Agrawal(S),Mishra(SP),Kumar(R),M... Transl Res 2025-10-00

...CTSL) emerged as particularly relevant for their multifaceted roles in inflammation, iron homeostasis, and matrix remode...

Cathepsin L and transmembrane serine protease 11E mediate trypsin-independent...

Xiao(W),Xiong(Y),Wang(Y),Li(T),Chen(C),Shi... J Virol 2025-09-23

...CTSL) and transmembrane serine protease 11E (TMPRSS11E) mediate these pathways, respectively. Mechanistically, CTSL and ...

Identification of proteases associated with glioblastoma and their modulation...

Oropeza-Maetínez(E),Palacios-Serrato(EG),M... Eur Cytokine Netw 2025-09-30

...CTSL) was upregulated by IFN-γ. Then, we analyzed the modulation of CTSL by IFN-γ in glioblastoma cells using dot blot, ...

Sodium nitrate protects against metabolic syndrome by sialin-mediated macroph...

Li(S),Wang(Y),Zhang(Z),Xu(H),Wu(S),Jin(H),... Signal Transduct Target The... 2025-10-02

...CtsL) expression and thereby activates the Nrf2 pathway to modulate macrophage homeostasis and ameliorate metabolic abno...

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