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Sharma(Sandeep K),Chorell(Erik),Steneberg(... Sci Rep 2016-07-28

...IAPP), i.e. peptides associated with Alzheimer's disease and type 2 diabetes, respectively. In addition to the protease ...

Park(Hongsuk),Cho(Sungpil),Han(Yong Hwan),... J Control Release 2016-02-08

The combinatorial peptidergic therapy of islet amyloid polypeptide (IAPP) and leptin (LEP) analogues was once an optimis...

Li(Zhiying),Kelly(Leah),Heiman(Myriam),Gre... Cell Metab 2016-10-19

...Iapp, precursor to amylin) is expressed in neurons in the lateral hypothalamus, arcuate nucleus, medial preoptic area, a...

Teichenne(Joan),Morró(Meritxell),Casellas(... PLoS One 2016-06-23

...IAPP, NeuroD1 and Pax4). miRNome panels were used to analyze differentially expressed miRNAs in acinar cells under four ...

Wong(Amy G),Wu(Chun),Hannaberry(Eleni),Wat... Biochemistry 2016-06-14

...IAPP (Takifugu rubripes) is known and is the most divergent from human IAPP of any reported IAPP sequence, differing at ...

Hatami(Asa),Monjazeb(Sanaz),Glabe(Charles) J Alzheimers Dis 2016-11-04

...IAPP). The recognition of amyloid fibrils is aggregation-dependent because 4G8 does not recognize α-synuclein or IAPP mo...

Akter(Rehana),Cao(Ping),Noor(Harris),Ridgw... J Diabetes Res 2016-10-05

...IAPP amyloid formation in vivo or in vitro are not understood and the mechanisms of IAPP induced β-cell death are not fu...

Rulifson(Ingrid C),Cao(Ping),Miao(Li),Kope... PLoS One 2016-07-12

...IAPP) is a hallmark pathological feature of type 2 diabetes. IAPP is stored in the secretory granules of pancreatic beta...

Westwell-Roper(Clara),Denroche(Heather C),... J Biol Chem 2016-11-03

...IAPP-induced proIL-1β synthesis. Soluble IAPP species produced early during IAPP aggregation provided a Toll-like-recept...

Venkatanarayan(Avinashnarayan),Raulji(Paya... Cell Cycle 2016-10-18

...IAPP, GLS2, and TIGAR resulting in an increase in apoptosis and tumor regression in ΔNp63/ΔNp73/p53 deficient thymic lym...