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SOX4-Mediated Post-transcriptional Suppression of PTEN via miR-106b∼25 Cluster …

Sun(F),Gao(L),Wang(M),Liu(P),Wang(B),Hu(J),W… Mol Cancer Res 2026-01-02

...SOX4 expression is increased in patients with prostate cancer with low PTEN levels, and the expression of SOX4 and PTEN ...

The long noncoding RNA AC093895.1 promotes ovarian cancer formation and metasta…

Huang(B),An(H),Qiu(Y),Ni(Z),Chen(L),Lin(J),L… Cell Death Dis 2026-02-03

...SOX4 could bind to the AC093895.1 promoter, forming a positive feedback loop SOX4/AC093895.1/miR-1253/SOX4. Therapeutic ...

TGFβ signaling promotes cell cycle progression and resistance to the CDK4/6 inh…

Ali(MM),Itoh(Y),Badji(AMP),Gallant(S),Tsirig… Cell Death Dis 2026-02-04

...SOX4 binding motifs in oncogenic cells. Transcriptomic analyses unexpectedly revealed the upregulation of DNA replicatio...

SOX4-STAT6-MTHFD2 axis drives hepatocellular carcinoma progression and treatmen…

Tsai(CL),Yu(MC),Hsu(CL),Tang(HY),Lee(YS),Chi… Cell Death Dis 2026-01-03

...SOX4 in HCC cells. Genetic ablation or knockdown of SOX4 induced hypermethylation of the STAT6 promoter, suppressing its...

Critical role of transcription factor SOX4 in tubular epithelial cell dediffere…

Du(H),Jiao(B),Xing(J),Yang(D),Tran(M),Wang(P… Kidney Int 2026-01-00

...SOX4 in regulating TEC dedifferentiation and fibroblast activation in vitro. SOX4 was induced in the injured kidneys but...

From preneoplastic lesion to heterogenous tumor: recent insights into hepatobla…

Yang(J),Davidoff(AM),Murphy(AJ) Mol Cancer 2025-07-19

...SOX4-dependent, paracrine manner, to drive the proliferation of neighboring embryonal hepatoblastoma cells. WNT-signalin...

Targeting IGF1R Overcomes Armored and Cold Tumor Microenvironment and Boosts Im…

Wan(M),Mei(J),Cai(Y),Zhou(J),Xue(N),Jiang(Y)… Adv Sci (Weinh) 2025-10-00

...SOX4 and DDR1, respectively. It is also found that IGF1R promotes tumor cell migration and invasion, as well as T cell e...

Chromatin landscape alteration uncovers multiple transcriptional circuits durin…

Liu(Q),Dong(W),Liu(R),Xu(L),Ran(L),Xie(Z),Le… Protein Cell 2025-07-19

...Sox4 and Nrf2 in developing memory precursor effector and effector memory cells, respectively, and validate cell state-s...

VEGFA and APOE regulate distinct functional states of mast cells in hepatocellu…

Lv(X),Chen(J),Abuduhailili(X),Deng(Y),Yuan(X… Int J Biol Macromol 2025-09-00

...SOX4, VEGFA), and transcriptional network analysis highlighted JUND, NF-κB, REL, and CREM as potential co-regulators of ...

miRNA-338-3p influences the liver cancer stem cells and lenvatinib resistance p…

Yuan(Y),Li(HF),Liu(ZM),Yu(LP) Sci Rep 2025-07-18

...SOX4 in liver CSCs. Moreover, miR-338-3p-associated downregulation of SOX4 prevents tumorigenesis and self-renewal in th...

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