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Transcriptional landscape of CD4+ T cells in Systemic Sclerosis.

Villanueva-Martin(G),Borrego-Yaniz(G),Acosta… bioRxiv 2026-03-19

...SOX4 and CD83, alongside an expansion of Th2 and proinflammatory, steroid-resistant Th17 cells. Furthermore, Tregs exhib...

Aging restricts maturation of CXCL13+ T follicular helper cells in human immuni…

Bracey(NA),Beppler(C),Bilich(T),Long(AH),Sol… bioRxiv 2026-04-07

...SOX4 as transcriptional regulators of differentiation reduced with age. These findings reveal a human-specific mechanism...

SOX4 is a transcriptional activator for CTHRC1 in lung fibroblast activation.

Huang(Y),Wu(L),Feng(D),Zhang(C),Zhuang(L),Ji… Gene 2026-07-10

...SOX4 positively regulates CTHRC1 expression at both mRNA and protein levels. Functional assays showed that SOX4 silencin...

Integration of human and mouse single-cell transcriptomes of the developing cer…

Cheong(I),Lau(L),Pai(S) BMC Cancer 2026-04-18

...SOX4, and SOX11. Our work provides initial evidence for human-enriched UBC states and suggests that SOX4 and SOX11 may d...

MYC-induced USP10 stabilizes SOX4 to promote thymocyte proliferation and leukem…

Zhang(M),Wu(H),Lin(X),Zhao(F),Deng(Q),Lu(L),… Nat Commun 2026-04-02

...SOX4, de-ubiquitinating and protecting SOX4 from degradation to promote thymocyte proliferation, with SOX4 overexpressio...

M6A-dependent upregulation of ZNF460 promotes epithelial-mesenchymal transition…

Yue(B),Song(C),Bao(T),He(W),Du(J),Yang(L),Zh… Oncogene 2026-05-00

...SOX4, thereby contributing to the tumor EMT and metastasis. In addition, the ZNF460/USP22/PHF8 complex enhances the tran...

Elucidating the roles of microRNA-103a-3p in trophoblast invasion and SOX4-medi…

Xie(J),Shannon(MJ),Zhu(H),Dong(M),Beristain(… Cell Death Dis 2026-04-10

...SOX4 (SRY-box transcription factor 4) and miR-103a-3p induced by activin A contributes to trophoblast invasion and poten...

Single-Cell RNA Sequencing Reveals the Role of Macrophage-Granulosa Cell Crosst…

Zhang(C),Yan(C),Wei(W),Dong(T),Jitjumnong(J)… FASEB J 2026-03-31

...SOX4, FLI1, and FOXO1. In addition, we found the gene expression level of IGFBP2 in the HU group was significantly upreg...

Knockdown of SOX4 attenuates sepsis myocardial injury by inhibiting the EZH2/H3…

Zhao(H),Tao(W),Huang(R),Cao(J),Xu(C) Mamm Genome 2026-03-09

...SOX4 and EZH2 increased, while the expression of SOCS3 decreased. Knockdown of SOX4 enhanced AC16 cell viability and inh...

Bovine colostrum exosomes mediate anti-inflammatory responses in macrophages vi…

Yang(M),Xu(H),Liang(Q),Wu(Y),Zhang(W),Nie(C)… J Dairy Sci 2026-05-00

...SOX4. Furthermore, miR-30a-5p mimic transfection recapitulated the anti-inflammatory effect by downregulating SOX4 and a...

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