Zhang(Q),Zhou(Y),Zhao(J),Hu(L),Zhu(Z),Wang(H… J Med Chem 2025-07-24

...SPOP are rarely reported. Here, we identified DDO-4033 as a potent SPOP inhibitor through virtual screening and optimiza...

Fiorentino(V),Germanà(E),Ricciardi(G),Capodi… Pathologica 2025-09-00

...SPOP interfering-RNA in two PCa cell lines (LNCaP, PC3) and western-blot analysis, we examined the role of SPOP silencin...

Maheremu(M),Zheng(B),Wen(H),Wei(Q),Lv(S) Transl Androl Urol 2025-07-30

...SPOP. We hypothesized that DDX17 can stabilize the AR by inhibiting SPOP-mediated ubiquitination, thereby maintaining AR...

Suh(M),O(JH) Nucl Med Mol Imaging 2025-10-00

...SPOP alterations. These genomic differences could influence PSMA expression and responsiveness to therapy. Additionally,...

Pedroza-Torres(A),Baranda-Avila(N),Ramírez(J… Int J Mol Sci 2025-09-09

...SPOP, TP53, FOXA1, and MTOR had the highest rate of pathogenic mutations in tumors, evidencing their relevance in PCa. A...

Wang(X),Yang(X),Xing(L),Chen(H),Xie(F),Wang(… Adv Sci (Weinh) 2025-12-00

...SPOP to suppress the Twist1 ubiquitination degradation and enhances PD-L1 transcriptional activity, thus promoting EMT, ...

Zhu(Z),Zhou(X),Xu(M),Chen(J),Robertson(KC),A… J Clin Invest 2025-12-15

...SPOP inhibitors not only blocked STING recognition by SPOP, but also acted as molecular glues, redirecting SPOP to targe...

Fizazi(K),de Bono(JS),Laird(AD),Barthélémy(P… Eur Urol Oncol 2025-12-00

...SPOP. ORRs were 30.0% and 34.5% in men with TP53 and PTEN alterations, respectively, and 28.6% and 26.8% in men without ...

Ye(Y),Yue(C),Zheng(Z),Ruan(H),Zhang(Y),Miao(… JCI Insight 2025-10-22

...SPOP-mediated apoptosis and SPOP deficiency-mediated necroptosis. Besides, inhibition or loss of RIPK3 rescued SPOP defi...

Yang(B),Yang(J),Xia(W),Zhang(Q),Zhang(P),Jin… World J Surg Oncol 2025-10-21

...SPOP (3% vs. 30%, P = 0.012) mutations were significantly enriched in patients with low Gleason scores. Chinese patients...