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Alterations of negative regulators of cytokine signalling in immunodeficiency...

Capello(Daniela),Gloghini(Annunziata),Bald... Hematol Oncol 2013-04-30

...SOCS3 epigenetic silencing were occasionally detected, whereas SOCS1 was frequently mutated in diffuse large B-cell lymp...

Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity.

Jorgensen(Sebastian Beck),O'Neill(Hayley M... Diabetes 2013-03-08

...SOCS3 in this tissue has not been examined. Therefore, we generated mice that had SOCS3 specifically deleted in skeletal...

Silencing of microRNA-122 enhances interferon-α signaling in the liver throug...

Yoshikawa(Takeshi),Takata(Akemi),Otsuka(Mo... Sci Rep 2013-02-14

...SOCS3). This decrease in SOCS3 level was not mediated by microRNA target gene suppression, but rather by enhanced methyl...

Reciprocal roles of STAT3 and STAT5 in nasal polyposis.

Wang(Xiao-Qiang),Hu(Guo-Hua),Kou(Wei),Shen... Am J Otolaryngol 2013-05-07

...SOCS3, RORc, Foxp3, IL-17A, and TGF-β1 were measured in patients with atopic NP, patients with nonatopic NP, and control...

STAT3 signal transduction through interleukin-22 in oral squamous cell ...

Naher(Lutfun),Kiyoshima(Tamotsu),Kobayashi... Int J Oncol 2013-03-22

...SOCS3. IL-22 transiently activated ERK1/2 and induced a delayed phosphorylation of p38 MAP kinase, but negli...

Engagement of T-cell antigen receptor and CD4/CD8 co-receptors induces prolon...

Chueh(Fu-Yu),Yu(Chao-Lan) Biochem Biophys Res Commun 2013-01-31

...SOCS3 and cytokine-inducible SH2 containing protein that are negative feedback regulators of STAT signaling. Moreover, e...

Sustained submicromolar H2O2 levels induce hepcidin via signal transducer and...

Millonig(Gunda),Ganzleben(Ingo),Peccerella... J Biol Chem 2013-01-07

...SOCS3 (suppressor of cytokine signaling 3), and antioxidants such as N-acetylcysteine. Glycoprotein 130 (gp130) is requi...

Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regula...

Liang(Pei),Cheng(Suk Hang),Cheng(Chi Keung... Haematologica 2013-11-25

...SOCS3, a STAT3 inhibitor, and gene silencing of SOCS3 abolished its ability to inhibit STAT3 activation, suggesting a cr...

Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellu...

Li(Youxing),Zhang(Qi),Liu(Yin),Luo(Zhen),K... J Virol 2013-01-14

...SOCS3). Our results also demonstrate that multiple signaling cascades, including several members of the protein kinase C...

Decreased interferon-α and interferon-β production in obesity and expression ...

Teran-Cabanillas(Eli),Montalvo-Corral(Mari... Nutrition 2013-05-13

...SOCS3 but not SOCS1. However, after stimulation, the expression of SOCS3 and SOCS1 mRNA was significantly lower in PBMCs...

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