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Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-bo...

da Fonseca(Paula C A),Kong(Eric H),Zhang(Z... Nature 2011-02-28

...Apc2. Cdh1 and Apc10, identified from difference maps, create a co-receptor for the D-box following repositioning of Cdh...

FBG1 is a promiscuous ubiquitin ligase that sequesters APC2 and causes S-phas...

Wen(Hsiang),Kim(Namhun),Fuentes(Ernesto J)... Cell Cycle 2011-03-23

...APC2 levels. However, free APC2 is decreased, inhibiting cell proliferation. Finally, FACS analysis of cell populations ...

Structural basis for the subunit assembly of the anaphase-promoting complex.

Schreiber(Anne),Stengel(Florian),Zhang(Zig... Nature 2011-02-28

...Apc2, Apc11 and Apc10 (also known as Doc1)), and TPR-phosphorylation sites, relative to co-activator, regulatory protein...

The anaphase promoting complex is required for memory function in mice.

Kuczera(Tanja),Stilling(Roman Manuel),Hsia... Learn Mem 2011-04-11

...Apc2 deletion in a mouse model for Alzheimer's disease. In our experimental setting loss of APC2 form principle forebrai...

Substrate binding on the APC/C occurs between the coactivator Cdh1 and the pr...

Buschhorn(Bettina A),Petzold(Georg),Galova... Nat Struct Mol Biol 2011-02-11

...Apc2-Apc11 in the inner cavity of the APC/C. Substrate proteins also bind in the inner cavity, in close proximity to Doc...

Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform mi...

Mattie(Floyd J),Stackpole(Megan M),Stone(M... Curr Biol 2011-04-04

...Apc2-GFP and Apc-RFP to branch points suggests that these proteins work together at dendrite branches. The functional im...

Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 revea...

Zhang(Ziguo),Roe(S Mark),Diogon(Marie),Kon... J Mol Biol 2010-05-25

...Apc2 and Apc11, respectively, and a tetratricopeptide repeat (TPR) sub-complex composed of the TPR subunits Cdc16, Cdc23...

Effete-mediated degradation of Cyclin A is essential for the maintenance of g...

Chen(Dongsheng),Wang(Qi),Huang(Haidong),Xi... Development 2010-02-09

...APC2, a key component of the anaphase-promoting complex (APC), which acts as a multisubunit E3 ligase and plays an essen...

Apical constriction and invagination downstream of the canonical Wnt signalin...

Zimmerman(Sandra G),Thorpe(Lauren M),Medra... Dev Biol 2010-05-24

...APC2 APC1 double null clones in the Drosophila wing imaginal disc. APC loss leads to segregation, apical constriction, a...

Distinct high-profile methylated genes in colorectal cancer.

Mokarram(Pooneh),Kumar(Krishan),Brim(Hassa... PLoS One 2010-02-01

...APC2, GPNMB, EVL, PTPRD, and STARD8, whereas methylation was <50% for LGR6, RET, CD109, and RNF. The difference in methy...

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